Immunologic tolerance to DNA in B cell lines from both normal and autoimmune mice.
Immunologic tolerance to DNA in B cell lines from both normal and autoimmune mice.
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正常小鼠和自身免疫小鼠 B 细胞系对 DNA 的免疫耐受性。
DOI：
10.1007/bf02935511
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发表时间：
1989
影响因子：
4.4
通讯作者：
Borel,Y
中科院分区：
文献类型：
--
作者：
Aldo-Benson,M;Borel,H;Scheiderer-Pratt,L;Borel,Y
我们研究了来自自身免疫小鼠 (BWF1) 或正常小鼠 (Balb/c) 的 DNA 特异性富集的 B 细胞系是否会因直接抗体形成细胞对 DNA 的特异性抑制而对自身抗原无反应。这些 B 细胞系 Lyt-1 呈阳性和阴性。与小鼠 γ 球蛋白共价连接的寡核苷酸预孵育可特异性抑制两种小鼠品系 B 细胞系中 DNA 马红细胞引起的抗原驱动反应。 BWF1 和 Balb/c 小鼠 B 细胞系对 DNA 特异性耐受诱导的敏感性存在 5 倍差异。因此，来自自身免疫小鼠的B细胞在对自身抗原产生耐受性方面似乎并不具有固有的绝对缺陷，但与非自身免疫细胞系相比，对DNA特异性耐受性的敏感性相对较低。
We examine whether B cell lines enriched for DNA specificity from either autoimmune (BWF1) or normal mice (Balb/c) can be rendered unresponsive to autoantigen in terms of the specific suppression of direct antibody-forming cells to DNA. These B cell lines were both Lyt-1 positive and negative. Preincubation with oligonucleotide, covalently linked to mouse γ-globulin, specifically suppressed the antigendriven response elicited by DNA horse red blood cells in B cell lines from both strains of mice. There is a 5-fold difference in susceptibility to DNA-specific tolerance induction between B cell lines of BWF1and Balb/c mice. Thus, B cells from autoimmune mice do not appear to have an inherent absolute defect in being rendered tolerant to autoantigen, but are relatively less susceptible to DNA-specific tolerance than nonautoimmune cell lines.