Bone mass density and bone metabolism marker are associated with progression of carotid and cardiac calcified plaque in Chinese elderly population
Bone mass density and bone metabolism marker are associated with progression of carotid and cardiac calcified plaque in Chinese elderly population
复制标题
骨质量密度和骨代谢标志物与中国老年人颈动脉和心脏钙化斑的进展相关
DOI：
10.1007/s00198-019-05031-5
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发表时间：
2019-09-01
影响因子：
4
通讯作者：
Zhou, R.
中科院分区：
文献类型：
--
作者：
Liu, D.;Chen, L.;Zhou, R.
骨质疏松症和心血管疾病常同时存在于同一个老年个体中。这是否表明这两种疾病之间存在某种潜在的相关性？低骨量和骨生物标志物的变化与颈动脉和心脏钙化斑块的风险增加有关。IntroductionBone mineral density（BMD）和骨代谢标志物可能有助于颈动脉和心脏动脉钙化的进展。本研究的目的是探讨是否低骨量和骨生物标志物的变化与钙化动脉粥样硬化斑块的患病率在老年Chinese.MethodsWe进行了为期五年的前瞻性研究。采用双能X线骨密度仪测量骨密度。颈动脉和心脏计算机断层扫描血管造影（CTA）进行了使用64多排扫描仪，以评估颈动脉和心脏动脉斑块在基线和随访期间。510例（32.5%）患者出现心脏钙化斑块，97例（6.2%）患者同时出现颈动脉和心脏钙化斑块。调整后的年龄和所有相关的混杂因素，Q1，Q2四分位数的BMD，骨保护素（OPG），骨钙素（OC），和C-末端交联端肽的I型胶原（CTX）与钙化plaques.ConclusionThis研究表明，较低的BMD和骨代谢生物标志物的变化与颈动脉和心脏钙化斑块发展的风险较高。
SummaryOsteoporosis and cardiovascular diseases often coexist in the same elderly individuals. Does this suggest some potential correlation between the two diseases? Low bone mass and change of bone biomarker are associated with a higher risk of carotid and cardiac calcification plaques.IntroductionBone mineral density (BMD) and bone metabolism marker may contribute to the progression of carotid and cardiac arterial calcifications. The aim of this study was to investigate whether low bone mass and the change of bone biomarker are associated with the prevalence of calcified atherosclerotic plaque in elderly Chinese.MethodsWe conducted a five-year prospective study. BMD was measured by dual-energy X-ray absorptiometry scanning. Carotid and cardiac computed tomography angiography (CTA) was conducted using a 64-multidetector row scanner to assess carotid and cardiac arterial plaque at baseline and during follow-up.ResultsOf 1571 community residents over 60 years of age, 184 (11.7%) subjects developed carotid calcified plaque, 510 (32.5%) subjects developed cardiac calcified plaque and 97 (6.2%) subjects developed co-existence calcified plaques in carotid and cardiac arteries. After adjustment for age and all relevant confounders, Q1, Q2 quartile of BMD, and osteoprotegerin (OPG), osteocalcin (OC), and C-terminal cross-linked telopeptide of type I collagen (CTX) were associated with increased risk of calcified plaques.ConclusionThis study suggested that lower BMD and change of bone metabolism biomarker were associated with a higher risk of carotid and cardiac calcified plaque development.