A paradigm for the development and evaluation of novel implant topologies for bone fixation: in vivo evaluation.
A paradigm for the development and evaluation of novel implant topologies for bone fixation: in vivo evaluation.
复制标题
用于骨固定的新型种植体拓扑的开发和评估范例：体内评估。
DOI：
10.1016/j.jbiomech.2012.08.011
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发表时间：
2012
影响因子：
2.4
通讯作者：
Goldstein,StevenA
中科院分区：
文献类型：
--
作者：
Long,JasonP;Hollister,ScottJ;Goldstein,StevenA
虽然当代的假肢设备可以为失去肢体的人恢复一些功能，但人们正在努力开发生物集成假肢来改善功能。推进这项技术的关键一步将是将设备安全地附着在残余的骨头上。为了研究在承受载荷时在骨中建立坚固的种植体固定的机制，我们之前使用拓扑优化方案开发优化的骨科种植体，然后使用选择性激光烧结（SLS）技术从钛（Ti）合金中制作选定的设计。在本研究中，我们研究了种植体结构和机械刺激如何影响体内环境下的骨整合。为此，我们使用一种独特的体内模型评估了三种种植体设计（两种优化的和一种非优化的），该模型对种植体施加循环张力/压缩载荷。18只成年公犬（每种植入物设计6只）通过手术将植入物放置在其胫骨近端。试验期12周；在后六周，每只动物的双侧植入物施加每日负荷（峰值负荷为±22N， 1000个周期）。收获后，通过非破坏性力学测试、微计算机断层扫描（microCT）和后向散射扫描电子显微镜（SEM）评估骨整合。数据显示，种植体载荷通过显著增加构建体刚度、种植体周围小梁形态、界面连通性和骨长入的百分比来增强骨整合。虽然该实验没有证明优化的种植体设计有明显的优势，但发现骨整合受到种植体结构方面的显著影响。
While contemporary prosthetic devices restore some function to individuals who have lost a limb, there are efforts to develop bio-integrated prostheses to improve functionality. A critical step in advancing this technology will be to securely attach the device to remnant bone. To investigate mechanisms for establishing robust implant fixation in bone while undergoing loading, we previously used a topology optimization scheme to develop optimized orthopedic implants and then fabricated selected designs from titanium (Ti)-alloy with selective laser sintering (SLS) technology. In the present study, we examined how implant architecture and mechanical stimulation influence osseointegration within an in vivo environment. To do this, we evaluated three implant designs (two optimized and one non-optimized) using a unique in vivo model that applied cyclic, tension/compression loads to the implants. Eighteen (six per implant design) adult male canines had implants surgically placed in their proximal, tibial metaphyses. Experimental duration was 12 weeks; daily loading (peak load of ±22N for 1000 cycles) was applied to one of each animal's bilateral implants for the latter six weeks. Following harvest, osseointegration was assessed by non-destructive mechanical testing, micro-computed tomography (microCT) and back-scatter scanning electron microscopy (SEM). Data revealed that implant loading enhanced osseointegration by significantly increasing construct stiffness, peri-implant trabecular morphology, and percentages of interface connectivity and bone ingrowth. While this experiment did not demonstrate a clear advantage associated with the optimized implant designs, osseointegration was found to be significantly influenced by aspects of implant architecture.