Plant Natural Products: Promising Resources for Cancer Chemoprevention.
Plant Natural Products: Promising Resources for Cancer Chemoprevention.
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DOI：
10.3390/molecules26040933
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发表时间：
2021-02-10
期刊：
影响因子：
--
通讯作者：
Li A
中科院分区：
文献类型：
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作者：
Ma L;Zhang M;Zhao R;Wang D;Ma Y;Li A
癌症是威胁人类健康和生命安全的主要因素，目前缺乏安全有效的治疗药物。对癌前过程进行干预和预防是逆转癌变、预防癌症发生的有效途径。植物天然产物来源丰富，是癌症化学预防的有希望的来源。本文综述了天然产物的化学预防作用，特别是多酚、类黄酮、单萜和三萜、含硫化合物和纤维素。并对其诱导凋亡、抗增殖、抑制转移等主要作用机制进行了综述。总之，这篇文章提供了天然产品仍然是癌症化学预防的重要来源的证据。
Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sources and are a promising source for cancer chemoprevention. This article reviews the chemopreventive effects of natural products, especially focused on polyphenols, flavonoids, monoterpene and triterpenoids, sulfur compounds, and cellulose. Meanwhile, the main mechanisms include induction of apoptosis, antiproliferation and inhibition of metastasis are briefly summarized. In conclusion, this article provides evidence for natural products remaining a prominent source of cancer chemoprevention.