COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.
COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.
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COMT Val 158 Met 多态性与轻度创伤性脑损伤后的非语言认知相关。
DOI：
10.1007/s10048-015-0467-8
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发表时间：
2016
期刊：
影响因子：
2.2
通讯作者：
Gar
中科院分区：
文献类型：
--
作者：
Winkler,EthanA;Yue,JohnK;McAllister,ThomasW;Temkin,NancyR;Oh,SamS;Burchard,EstebanG;Hu,Donglei;Ferguson,AdamR;Lingsma,HesterF;Burke,JohnF;Sorani,MarcoD;Rosand,Jonathan;Yuh,EstherL;Barber,Jason;Tarapore,PhirozE;Gar
Mild traumatic brain injury (mTBI) results in variable clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. However, this has been disputed, and its role in mTBI has not been studied. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether theCOMT Val158Metpolymorphism influences outcome on a cognitive battery 6 months following mTBI—Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), Trail Making Test (TMT) Trail B minus Trail A time, and California Verbal Learning Test, Second Edition Trial 1–5 Standard Score (CVLT-II). All patients had an emergency department Glasgow Coma Scale (GCS) of 13–15, no acute intracranial pathology on head CT, and no polytrauma as defined by an Abbreviated Injury Scale (AIS) score of ≥3 in any extracranial region. Results in 100 subjects aged 40.9 (SD 15.2) years (COMT Met158/Met15829 %,Met158/Val15847 %,Val158/Val15824 %) show that theCOMT Met158allele (mean 101.6 ± SE 2.1) associates with higher nonverbal processing speed on the WAIS-PSI when compared toVal158/Val158homozygotes (93.8 ± SE 3.0) after controlling for demographics and injury severity (mean increase 7.9 points, 95 % CI [1.4 to 14.3],p= 0.017). TheCOMT Val158Metpolymorphism did not associate with mental flexibility on the TMT or with verbal learning on the CVLT-II. Hence,COMT Val158Metmay preferentially modulate nonverbal cognition following uncomplicated mTBI.Registry: ClinicalTrials.gov Identifier NCT01565551
