Role of postoperative adjuvant radiotherapy for locally advanced laryngeal cancer: a meta-analysis
Role of postoperative adjuvant radiotherapy for locally advanced laryngeal cancer: a meta-analysis
复制标题
局部晚期喉癌术后辅助放疗的作用：一项荟萃分析
DOI：
10.1080/00016489.2018.1542159
复制
发表时间：
2019-02-01
影响因子：
1.4
通讯作者：
Zhang, Binglan
中科院分区：
文献类型：
--
作者：
Li, Minmin;Zhang, Tao;Zhang, Binglan
摘要背景：研究表明，术后辅助放疗（PORT）在手术治疗局部晚期喉癌中的作用结果不一。目的：本研究的目的是回顾和调查PORT在局部晚期喉癌患者中的作用，采用荟萃分析。材料和方法：使用PubMed检索相关研究，并提取合格信息。然后进行风险比（HR）的荟萃分析，以评估PORT在局部晚期喉癌中的作用。结果：该荟萃分析包括7项已发表的研究，包含2007例患者。对于总生存期（OS），与未接受PORT治疗的患者相比，接受PORT治疗的局部晚期喉癌患者的联合风险比（HR）为0.67，95%CI（0.56，0.79），这与更好的生存率显著相关。PORT还与局部晚期喉癌患者更好的无病生存率（DFS）和局部控制率（LCR）相关。DFS和LCR的合并HR和95%CI分别为0.72（0.53，0.99）和0.29（0.09，0.99）。结论及意义：这项研究表明，PORT可以提高手术治疗的局部晚期喉癌患者的生存率。
Abstract Background: Studies have shown mixed results on the role of postoperative adjuvant radiotherapy (PORT) in surgically managed locally advanced laryngeal cancer. Objectives: The aim of this study is to review and investigate the role of PORT in patients with locally advanced laryngeal cancer using meta-analysis. Materials and methods: Relevant studies were searched using PubMed and eligible information has been extracted. Then, meta-analysis of hazard ratio (HR) was performed to evaluate the role of PORT in locally advanced laryngeal cancer. Results: This meta-analysis included 7 published studies containing 2007 patients. For overall survival (OS), patients of locally advanced laryngeal cancer who were treated with PORT have a combined hazard ratio (HR) of 0.67 with 95%CI (0.56, 0.79), compared to those who were not treated with PORT, which was significantly associated with better survival. PORT was also associated with a better disease-free survival (DFS) and local control rate (LCR) in patients with locally advanced laryngeal cancer. The pooled HR and 95%CI for DFS and LCR were 0.72 (0.53, 0.99) and 0.29 (0.09, 0.99), respectively. Conclusions and significance: This study suggested that PORT could improve the survival of patients with surgically managed locally advanced laryngeal cancer.