Genomic Testing in Cancer Patient Knowledge, Attitudes, and Expectations
Genomic Testing in Cancer Patient Knowledge, Attitudes, and Expectations
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DOI：
10.1002/cncr.28807
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发表时间：
2014-10-01
期刊：
影响因子：
6.2
通讯作者：
Siu, Lillian L.
中科院分区：
文献类型：
--
作者：
Blanchette, Phillip S.;Spreafico, Anna;Siu, Lillian L.
背景：癌症基因组检测（GTC）表征在患者癌症发展和生长中起重要作用的基因。目前正在研究这种形式的DNA测试，以指导癌症治疗。本研究的目的是描述患者对GTC的知识、态度和期望。方法：由多学科小组和患者预测试开发了42项自我管理的GTC问卷。调查问卷分发给晚期癌症患者，他们被转诊到玛格丽特公主癌症中心进行1期临床试验或GTC测试。结果：结果来自98例晚期癌症患者，占调查患者的66%。76%的患者有兴趣了解更多关于GTC的信息，64%的患者报告GTC将显着改善他们的癌症护理。评估癌症基因组学知识的12项问卷的中位得分为12项中的8项正确（67%;四分位数范围，12项中的7-9项正确[58%-75%]）。文化程度越高，得分越高（P
BACKGROUND: Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patients' knowledge, attitudes, and expectations toward GTC. METHODS: A 42-item self-administered GTC questionnaire was developed by a multidisciplinary group and patient pretesting. The questionnaire was distributed to patients with advanced cancer who were referred to the Princess Margaret Cancer Center for a phase 1 clinical trial or GTC testing. RESULTS: Results were reported from 98 patients with advanced cancer, representing 66% of the patients surveyed. Seventy-six percent of patients were interested in learning more about GTC, and 64% reported that GTC would significantly improve their cancer care. The median score on a 12-item questionnaire to assess knowledge of cancer genomics was 8 of 12 items correct (67%; interquartile range, 7-9 of 12 items correct [58%-75%]). Scores were associated significantly with patients' education level (P