POLYPS OF THE LARGE-INTESTINE IN AARHUS, DENMARK - AN AUTOPSY STUDY
POLYPS OF THE LARGE-INTESTINE IN AARHUS, DENMARK - AN AUTOPSY STUDY
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DOI：
10.3109/00365528909089217
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发表时间：
1989-01-01
影响因子：
1.9
通讯作者：
JACOBSEN, NO
中科院分区：
文献类型：
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作者：
JOHANNSEN, LGK;MOMSEN, O;JACOBSEN, NO
在336例连续尸检中，共记录了305例大肠肿瘤。其中，184例腺瘤发生在196例男性中的26%和140例女性中的17%，导致总体患病率为22%，或标准化为世界标准人群（WSP）时为15%。腺瘤的患病率随着年龄的增长而增加，并且在老年组中发生了从远端到近端位置的转变，主要是由于老年人的多重性趋势更大。无论年龄大小，57%的腺瘤病例可以通过乙状结肠镜检查确定。增生性息肉的患病率为13%，并发现它们与腺瘤之间存在联系。除了一些例外情况，详细讨论，结果与其他国家的研究结果一致，这些国家的结直肠癌发病率高，社会经济构成相似。该研究支持腺瘤-癌序列的理论。
In 336 consecutive autopsies a total of 305 tumors were recorded in the large intestine. Of these, 184 were adenomas occurring in 26% of the 196 men and 17% of the 140 women, resulting in an overall prevalence of 22%, or 15% when standardized to the world standard population (WSP). The prevalence of adenomas increased with age, and a shift from distal to proximal location occurred in the older age groups, mostly accounted for by the greater tendency to multiplicity in old age. Regardless of age 57% of the cases of adenomas could have been identified by flexible sigmoidoscopy. The prevalence of hyperplastic polyps was 13%, and an association between these and adenomas was found. Five adenocarcinomas occurred in the study. With some exceptions, which are discussed in detail, the results are in accordance with studies from other countries with a high incidence of colorectal cancer and similar socioeconomic composition. The study supports the theory of the adenoma-carcinoma sequence.