Genetic control of recovery from visceral leishmaniasis.
Genetic control of recovery from visceral leishmaniasis.
复制标题
内脏利什曼病恢复的基因控制。
DOI：
10.1016/0035-9203(82)90262-0
复制
发表时间：
1982
影响因子：
2.2
通讯作者：
Jenefer M. Blackwell
中科院分区：
文献类型：
--
作者：
Jenefer M. Blackwell
Bradley and Kirkley [seeTrop. Dis. Bull., 1978,75, abst. 1326] noted that both inbred NMRI mice and outbred PO mice were strains innately susceptible toLeishmania donovanias judged by their parasite loads 2-4 weeks after infection. Over a longer period of observation, however, it was noted that NMRI mice but not PO mice resolved their infections. When the livers of the infected mice of both strains were examined histologically 2 weeks after infection they were full of granulomata comprising mainly parasitized and unparasitized macrophages. In NMRI mice, by 80 days after infection, however, the granulomata contained macrophages, many lymphocytes and very few parasites and after 4-5 months there were few granulomata and the liver was almost back to normal. In contrast, the PO mice had heavily parasitized livers with numerous granulomata for more than 2 years. This pattern of "cure" or "non-cure" in the innately susceptible mice was also seen in the innately resistant mice. In this paper Blackwell discusses the genetic control of the later stages ofL. donovaniinfection in innately susceptible mouse strains.To start with she examined the possible role of the major histocompatibility complex of the mouse, H-2, using congenie strains of mice such as B10 and B10.D2. B10 mice are haplotype H-2band B10.D2 are haplotype H-2d. In crossing experiments the curing trait behaved as a recessive Mendelian trait. There was a 100% correlation between homozygous b/b haplotype with cure and between homozygous d/d and heterozygous b/d haplotypes with non-cure. Experiments with other haplotypes on a B10 genetic background confirmed that H-2 exerts a major influence in controlling the course ofL. donovaniinfection. When H-2band H-2dhaplotypes were put onto other genetic backgrounds such as BALB/c, again H-2bcorrelated with a reduction of parasite load while H-2dmice were non-curing. There was, however, considerable variation between strains suggesting that non-H-2 linked genes influence the rate of recovery in some strains.[See also the previous and 2 following abstracts.]R.S. Phillips.
