Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue.
Dynamic Encoding of Incentive Salience in the Ventral Pallidum: Dependence on the Form of the Reward Cue.
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DOI：
10.1523/eneuro.0328-17.2018
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发表时间：
2018-03
期刊：
影响因子：
3.4
通讯作者：
Aldridge JW
中科院分区：
文献类型：
--
作者：
Ahrens AM;Ferguson LM;Robinson TE;Aldridge JW
一些大鼠特别倾向于将激励性显著归因于线索(条件刺激，CS)和食物奖励(信号追踪器，STS)，但它们这样做的程度随着条件刺激的形式而不同。其他大鼠主要对线索(目标追踪器，GTS)的预测值做出反应，无论其形式如何。与目标跟踪相比，手势跟踪与线索诱导的边缘中结构的激活程度更高；然而，尚不清楚CS本身的形式如何影响参与激励性显著归因的神经系统的活动。因此，我们的目标是确定不同的线索形式如何影响腹侧苍白球(VP)的神经活动，腹侧苍白球(VP)已知编码激励性显著归因，在大鼠执行两个CS巴甫洛夫条件接近任务时，Level-CS和Tone-CS都预测相同的食物奖励。Level-CS在一些大鼠(STS)中引发手势跟踪，在另一些大鼠(GTS)中引发目标跟踪，而Tone-CS只在所有大鼠中引发目标跟踪。相对于GTS，LEVEL-CS在整个STS的VP的神经活动(持续紧张性放电的增加或减少)中引起了强烈的变化。当STS暴露于Tone-CS时，这些变化不明显，而在GTS中，Level-CS和Tone-CS之间的放电没有差异。我们的结论是，整个VP的神经活动编码激励信号，当线索的形式促进对激励显著的归因时，尤其是在有倾向的个体中，尤其是在倾向于它的个体中，特别是当线索的形式促进对其的激励显著归因时，尤其是在有倾向的个体中。
Some rats are especially prone to attribute incentive salience to a cue (conditioned stimulus, CS) paired with food reward (sign-trackers, STs), but the extent they do so varies as a function of the form of the CS. Other rats respond primarily to the predictive value of a cue (goal-trackers, GTs), regardless of its form. Sign-tracking is associated with greater cue-induced activation of mesolimbic structures than goal-tracking; however, it is unclear how the form of the CS itself influences activity in neural systems involved in incentive salience attribution. Thus, our goal was to determine how different cue modalities affect neural activity in the ventral pallidum (VP), which is known to encode incentive salience attribution, as rats performed a two-CS Pavlovian conditioned approach task in which both a lever-CS and a tone-CS predicted identical food reward. The lever-CS elicited sign-tracking in some rats (STs) and goal-tracking in others (GTs), whereas the tone-CS elicited only goal-tracking in all rats. The lever-CS elicited robust changes in neural activity (sustained tonic increases or decreases in firing) throughout the VP in STs, relative to GTs. These changes were not seen when STs were exposed to the tone-CS, and in GTs there were no differences in firing between the lever-CS and tone-CS. We conclude that neural activity throughout the VP encodes incentive signals and is especially responsive when a cue is of a form that promotes the attribution of incentive salience to it, especially in predisposed individuals.