Decoding the organization of spinal circuits that control locomotion.
Decoding the organization of spinal circuits that control locomotion.
复制标题
DOI：
10.1038/nrn.2016.9
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Kiehn O
中科院分区：
文献类型：
--
作者：
Kiehn O
揭开神经元网络的功能运作，并将细胞活动与特定的行为结果联系起来，是神经科学面临的最大挑战之一。在这一广泛的研究领域中，控制运动的脊髓网络研究取得了实质性进展。通过使用电生理学和分子遗传网络方法以及在遗传多样性实验模型中的行为研究的联合努力，运动网络的组织已经开始被解码。这项研究的新主题是，运动网络具有模块化组织，具有不同的发射器和分子代码，并且它们的组织随着运动速度或步态的变化而重新配置。
Unravelling the functional operation of neuronal networks and linking cellular activity to specific behavioural outcomes are among the biggest challenges in neuroscience. In this broad field of research, substantial progress has been made in studies of the spinal networks that control locomotion. Through united efforts using electrophysiological and molecular genetic network approaches and behavioural studies in phylogenetically diverse experimental models, the organization of locomotor networks has begun to be decoded. The emergent themes from this research are that the locomotor networks have a modular organization with distinct transmitter and molecular codes and that their organization is reconfigured with changes to the speed of locomotion or changes in gait.