Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse.
Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse.
复制标题
小鼠 x 染色体连接的磷酸甘油酸激酶 (pgk-1) 的电泳变异。
作者：
J. T. Nielsen;V. Chapman
在丹麦的野生小鼠中，X染色体连锁磷酸甘油酸激酶（PGK-1）的电泳变异被发现是一种多态性。来自野生动物采样或来自各种遗传杂交的雄性仅具有在近交系小鼠中常见的变体PGK-1A型或PGK-1B型的单带表型。相比之下，三个表型中观察到的女性;两个纯合的单带型和杂合的双带型。根据F（1）和回交世代的遗传方式确定了Pgk-1基因座的X染色体连锁，并通过Pgk-1与X连锁标记Hq、Ta和Mo的连锁得到证实。Pgk-1与Hq的重组率为29/122，与Ta的重组率为5/185，与Mo的重组率为0/108。根据这些重组数据，提出了Hq-Ta-Pgk-1-Mo的基因顺序。
Electrophoretic variation for X-chromosome-linked phosphoglycerate kinase (PGK-1) has been found as a polymorphism in feral mice in Denmark. Males from feral sampling or from a variety of genetic crosses have only a single-banded phenotype of the variant PGK-1A type or of the PGK-1B type commonly found among inbred mice. By contrast, three phenotypes were observed among females; two homozygous single-banded types and a heterozygous double-banded type. The X-chromosome linkage of the Pgk-1 locus was determined from the mode of inheritance in F(1) and backcross generations and confirmed by the linkage of Pgk-1 and the X-linked markers Hq, Ta and Mo. Pgk-1 showed 29/122 recombinations with Hq, 5/185 with Ta and 0/108 recombinants with Mo. Based on these recombination data, a gene order of Hq-Ta-Pgk-1-Mo is suggested.