Renal cell carcinoma and occupational exposure to chemicals in Canada
Renal cell carcinoma and occupational exposure to chemicals in Canada
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DOI：
10.1093/occmed/52.3.157
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
White, K
中科院分区：
文献类型：
--
作者：
Hu, J;Mao, Y;White, K
本研究评估了职业暴露于特定化学品对加拿大肾细胞癌风险的影响。通过邮寄问卷的方式获取1994年至1997年间加拿大8个省1279例（691例男性和588例女性）新诊断、组织学证实的肾细胞癌病例和5370例人口对照的数据。收集的数据包括社会经济地位、吸烟习惯、饮酒情况、饮食、居住和职业历史，以及接触17种化学物质的年数。比值比（ORs）和95%置信区间（ci）采用无条件逻辑回归。研究发现，只有男性患肾细胞癌的风险增加，这与职业接触苯有关；联苯胺;煤焦油、煤烟、沥青、杂酚油或沥青；除草剂;矿物油、切削油或润滑油；芥子气;农药;还有氯乙烯。与未接触特定化学物质的对照组相比，调整后的or分别为1.8 （95% CI = 1.2 ~ 2.6）、2.1（1.3 ~ 3.6）、1.4（1.1 ~ 1.8）、1.6（1.3 ~ 2.0）、1.3（1.1 ~ 1.7）、4.6（1.7 ~ 12.5）、1.8（1.4 ~ 2.3）和2.0 (1.2 ~ 3.3)；接触镉盐和异丙基油也会增加患病风险。肾细胞癌的风险随着接触苯、联苯胺、镉、除草剂和氯乙烯的时间延长而增加。在这项研究中，很少有女性接触到特定的化学物质；需要进一步的研究来阐明职业接触化学物质与女性肾细胞癌之间的关系。
This study assesses the effect of occupational exposure to specific chemicals on the risk of renal cell carcinoma in Canada. Mailed questionnaires were used to obtain data on 1279 (691 male and 588 female) newly diagnosed, histologically confirmed renal cell carcinoma cases and 5370 population controls in eight Canadian provinces, between 1994 and 1997. Data were collected on socio-economic status, smoking habit, alcohol use, diet, residential and occupational histories, and years of exposure to any of 17 chemicals. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived using unconditional logistic regression. The study found an increased risk of renal cell carcinoma in males only, which was associated with occupational exposure to benzene; benzidine; coal tar, soot, pitch, creosote or asphalt; herbicides; mineral, cutting or lubricating oil; mustard gas; pesticides; and vinyl chloride. Compared with no exposure to the specific chemical, the adjusted ORs were 1.8 (95% CI = 1.2-2.6), 2.1 (1.3-3.6), 1.4 (1.1-1.8), 1.6 (1.3-2.0), 1.3 (1.1-1.7), 4.6 (1.7-12.5), 1.8 (1.4-2.3) and 2.0 (1.2-3.3), respectively; an elevated risk was also associated with exposure to cadmium salts and isopropyl oil. The risk of renal cell carcinoma increased with duration of exposure to benzene, benzidine, cadmium, herbicides and vinyl chloride. Very few females were exposed to specific chemicals in this study; further research is needed to clarify the association between occupational exposure to chemicals and renal cell carcinoma in females.