Risk Factors for Extended Duration and Timing of Peak Severity of Hot Flashes.
Risk Factors for Extended Duration and Timing of Peak Severity of Hot Flashes.
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DOI：
10.1371/journal.pone.0155079
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Flaws JA
中科院分区：
文献类型：
--
作者：
Smith RL;Gallicchio L;Miller SR;Zacur HA;Flaws JA
确定与中年女性潮热持续时间和潮热严重程度高峰时间相关的危险因素。对647名报告潮热的女性进行了为期1-7年的跟踪调查，并进行了调查数据和激素测量。生存分析确定了危险因素与潮热持续时间的关系。线性回归确定危险因素与严重程度达到峰值的时间之间的关联。通过逐步模型选择确定最终模型。潮热持续时间1~33年，平均2.5年，潮热高峰时间1~20年，平均2.96年。潮热的持续时间与种族、教育程度、更年期状态、吸烟史、体重指数、饮酒、休闲活动水平以及雌二醇和孕激素水平有关。在最终的模型中，只保留了种族、饮酒、休闲活动和更年期。白人女性的潮热持续时间明显短于非白人女性。与前一年饮酒少于12杯的女性相比，前一年至少饮用12杯酒精饮料的女性潮热持续时间明显缩短，潮热持续时间对潮热程度达到峰值的时间增加的影响较小。如果潮热持续时间少于2年，血清孕酮水平越高，峰值严重程度越晚，否则峰值严重程度越早。这些结果表明，某些行为(如适度饮酒)与潮热持续时间较短有关，黄体酮与潮热严重程度的动态变化有关。
To identify risk factors associated with the duration of hot flashes and the time of peak hot flash severity in mid-life women. A cohort of 647 women reporting hot flashes were followed for 1–7 years, with survey data and hormone measurements. Survival analysis determined the association of risk factors with the duration of hot flashes. Linear regression determined the association of risk factors with the time of peak severity. Final models were determined through stepwise model selection. Average hot flash duration was 2.5 years (range: 1–33), with peak severity on average at 2.96 years (range: 1–20). Duration of hot flashes was associated with race, education, menopause status, smoking history, BMI, alcohol consumption, leisure activity levels, and levels of estradiol and progesterone. In the final model, only race, alcohol consumption, leisure activity, and menopause were retained. White women had significantly shorter hot flash durations than non-white women. Women consuming at least 12 alcoholic drinks in the previous year had a significantly shorter duration of hot flashes with a smaller effect of hot flash duration on increasing in time to peak severity compared to those who consumed less than 12 alcoholic drinks in that year. Higher serum progesterone levels were associated with later peak severity if the duration of the hot flashes was less than 2 years and an earlier peak severity otherwise. These results suggest that some behaviors (such as moderate alcohol consumption) are associated with shorter durations of hot flashes, and that progesterone was associated with the dynamics of hot flash severity.