A Functional MRI Study of Human Amygdala Responses to Facial Expressions of Fear Versus Anger
A Functional MRI Study of Human Amygdala Responses to Facial Expressions of Fear Versus Anger
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DOI：
10.1037/1528-3542.1.1.70
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发表时间：
2001-03-01
期刊：
影响因子：
4.2
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
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作者：
Whalen, Paul J.;Shin, Lisa M.;Rauch, Scott L.
人脑的功能磁共振成像（fMRI）被用来比较与观看恐惧和愤怒的面部表情相关的杏仁核活动的变化。向 8 名健康参与者展示了带有恐惧或愤怒表情的人脸以及中性表情的人脸图片。与愤怒相比，背侧杏仁核内的血氧水平依赖性（BOLD）fMRI信号明显大于恐惧信号，形成直接对比。在恐惧与中性表达的对比中，以及在更空间限制的区域中，在愤怒与中性表达的对比中，观察到腹侧杏仁核中显着的 BOLD 信号变化。因此，与中性或愤怒的面部表情相比，杏仁核的活动对于恐惧的面部表情更活跃。此外，将恐惧与愤怒的面孔直接对比，凸显了背侧杏仁核区域的参与。
Functional magnetic resonance imaging (fMRI) of the human brain was used to compare changes in amygdala activity associated with viewing facial expressions of fear and anger. Pictures of human faces bearing expressions of fear or anger, as well as faces with neutral expressions, were presented to 8 healthy participants. The blood oxygen-level dependent (BOLD) fMRI signal within the dorsal amygdala was significantly greater to Fear versus Anger, in a direct contrast. Significant BOLD signal changes in the ventral amygdala were observed in contrasts of Fear versus Neutral expressions and, in a more spatially circumscribed region, to Anger versus Neutral expressions. Thus, activity in the amygdala is greater to fearful facial expressions when contrasted with either neutral or angry faces. Furthermore, directly contrasting fear with angry faces highlighted involvement of the dorsal amygdaloid region.