TFInfer: a tool for probabilistic inference of transcription factor activities
TFInfer: a tool for probabilistic inference of transcription factor activities
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DOI：
10.1093/bioinformatics/btq469
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发表时间：
2010-10-01
期刊：
影响因子：
5.8
通讯作者：
Sanguinetti, Guido
中科院分区：
文献类型：
--
作者：
Asif, H. M. Shahzad;Rolfe, Matthew D.;Sanguinetti, Guido
TFInfer是一种新型的开放获取，独立的工具，用于从基因表达数据中推断转录因子活性的全基因组。基于早期的MATLAB版本，该软件现在已经在许多方面进行了扩展。它在性能方面进行了显着优化，并通过允许用户从多个独立条件中对时间序列和数据进行建模，赋予了新的功能。该软件具有完整的文档和直观的图形用户界面，以及酵母和大肠杆菌转录因子的内置数据库，不需要任何数学或计算专业知识即可有效使用。
TFInfer is a novel open access, standalone tool for genome-wide inference of transcription factor activities from gene expression data. Based on an earlier MATLAB version, the software has now been extended in a number of ways. It has been significantly optimised in terms of performance, and it was given novel functionality, by allowing the user to model both time series and data from multiple independent conditions. With a full documentation and intuitive graphical user interface, together with an in-built data base of yeast and Escherichia coli transcription factors, the software does not require any mathematical or computational expertise to be used effectively.