Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation
Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation
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DOI：
10.1002/mrm.10370
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发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Kauppinen, RA
中科院分区：
文献类型：
--
作者：
Silvennoinen, MJ;Kettunen, MI;Kauppinen, RA
在本研究中，血液T-1被确定为红细胞压积和氧饱和度的函数。T-1对这两个参数均表现出显著的线性依赖性。此外，在高氧血中溶解在血浆中的氧导致松弛增强，其大小与由于血红蛋白的氧合状态的改变而引起的松弛增强相当。由于血液T-1是用动脉自旋标记方法定量血流的关键因素，因此讨论了T-1在红细胞压积和血氧饱和度的生理范围内的变化对血流测定的影响。(C)2003 Wiley-Liss，Inc.
In the present study blood T-1 was determined as a function of hematocrit and oxygen saturation. T-1 showed a significant linear dependency on both of these parameters. In addition, oxygen dissolved in blood plasma in hyperoxygenated blood resulted in relaxation enhancement, comparable in size to that due to the change in oxygenation state of hemoglobin. As blood T-1 is a key factor for quantification of flow with arterial spin labeling methods, the influence of T-1 variation in the physiological range of hernatocrit and oxygen saturation to flow determination is discussed. (C) 2003 Wiley-Liss, Inc.