Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration
Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration
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DOI：
10.1111/j.1524-475x.2005.00093.x
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Nakajima, T
中科院分区：
文献类型：
--
作者：
Kishi, K;Ohyama, K;Nakajima, T
哺乳动物胚胎在某些发育阶段的皮肤伤口显示完全再生。据报道，成人和胎儿皮肤中的伤口愈合都被去神经支配破坏。此外，胎儿皮肤再生具有独特的方面，例如取决于发育阶段的表皮皱纹纹理再生和真皮再生。因此，我们研究了胎儿皮肤再生与去神经支配的关系。我们在不同发育时间点（包括胚胎（E）13，E15和E17）的胎鼠上制作皮肤伤口，并比较皮肤中周围神经的再生模式。我们发现，当胎儿在发育早期受伤时，周围神经的再生速度比发育后期周围神经再生延迟时要快。然后，我们切断肋间神经，并在E13和E15的失神经部位制作伤口。我们发现，表皮再生和真皮再生被破坏去神经支配。这些发现表明，胎儿皮肤再生和周围神经再生的组成部分是相互依赖的。
Mammalian fetal cutaneous wounds made at certain developmental stages show complete regeneration. It is reported that wound healing in both adult and fetal skin is disrupted by denervation. Furthermore, fetal cutaneous regeneration has unique aspects such as epidermal wrinkle texture regeneration and dermal regeneration that depend on developmental stage. Therefore, we have examined the relationship of fetal cutaneous regeneration with denervation. We made cutaneous wounds on fetal mice at various developmental time points including embryonic days (E)13, E15, and E17, and compared the regenerating patterns of peripheral nerves in the skin. We found that when the fetuses are wounded at an early stage of development, peripheral nerves regenerate quicker than at later stages of development when peripheral nerve regeneration is delayed. Next, we denervated the intercostal nerves and made wounds at the denervated sites on E13 and E15. We found that epidermal wrinkling and dermal regeneration were disrupted by denervation. These findings indicate that components of fetal cutaneous regeneration and peripheral nerve regeneration are mutually dependent.