Disorders of glucose regulation in adults and birth weight - Results from the Australian diabetes, obesity and lifestyle (AusDiab) study
Disorders of glucose regulation in adults and birth weight - Results from the Australian diabetes, obesity and lifestyle (AusDiab) study
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DOI：
10.2337/dc07-1170
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发表时间：
2008-01-01
期刊：
影响因子：
16.2
通讯作者：
Shaw, Jonathan E.
中科院分区：
文献类型：
--
作者：
Al Salmi, Isa;Hoy, Wendy E.;Shaw, Jonathan E.
目的-本研究的目的是研究出生体重与指数的关联，在人口为基础的surveillance.Research设计和方法-共10,788名参与者在澳大利亚糖尿病，肥胖和生活方式（AusDiab）研究被要求完成出生体重问卷。根据出生体重对空腹血糖（FPG）、负荷后血糖（PLG）和AIC进行建模。世界卫生组织的标准被用来定义空腹血糖受损（IFG），糖耐量受损（IGT），和diabetes.RESULTS -在7,157名参与者谁回答问卷，4,502报告他们的出生体重，平均+/- SD为3.4 +/- 0.7公斤。FPG、PLG和AIC与出生体重呈强负相关。校正年龄和性别后，出生体重每增加1 kg，FPG、PLG和AIC升高（>第90性别百分位数）的比值比（95%CI）分别为0.83（0.71-0.96）、0.74（0.65-0.84）和0.81（0.70-0.94）。在低出生体重（LBW）人群中，与正常出生体重人群相比，女性IFG、IGT和糖尿病以及所有异常合并的风险分别增加1.75、2.22、2.76和2.28，男性分别增加1.40、1.32、1.98和1.49。这些趋势适用于不同类别的年龄和BMI.CONCLUSIONS -在一个富裕的西方国家有一个良好的成人健康状况，出生体重指数呈反比关系，LBW和个人倾向于更高的成年生活中的血糖失调率。这些关联独立于BMI和其他与血糖失调显著相关的因素。
OBJECTIVE - The purpose of this study was to examine the association of birth weight with indexes of glycemia in a population-based survey.RESEARCH DESIGN AND METHODS - A total of 10,788 participants in the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study were asked to complete a birth weight questionnaire. Fasting plasma glucose (FPG), postload glucose (PLG), and AIC were modeled against birth weight. World Health Organization criteria were used to define impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes.RESULTS - Among 7,157 participants who responded to the questionnaire, 4,502 reported their birth weights, with a mean +/- SD of 3.4 +/- 0.7 kg. FPG, PLG, and AIC were strongly and inversely correlated with birth weight. The odds ratios (95% CI) for high (> 90th sex-specific percentile) FPG, PLG, and AIC were 0.83 (0.71-0.96), 0.74 (0.65-0.84), and 0.81 (0.70-0.94), respectively, for a 1-kg increase in birth weight after adjustment for age and sex. In those with low birth weight (LBW), the risks for having IFG, IGT, and diabetes and for all abnormalities combined were increased by 1.75, 2.22, 2.76, and 2.28, respectively, for women and by 1.40, 1.32, 1.98, and 1.49 for men compared with risks for those with normal birth weight. These trends applied across categories of age and BMI.CONCLUSIONS - in an affluent Western country with a good adult health profile, birth weight has an inverse relationship with indexes of glycemia, and individuals with LBW were predisposed to higher rates of glycemic dysregulation in adult life. These associations were independent of BMI and of other factors significantly correlated with glycemic dysregulation.