Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension
Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension
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DOI：
10.1016/j.amjhyper.2006.08.001
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发表时间：
2007-02-01
影响因子：
3.2
通讯作者：
Adachi, Mitsuru
中科院分区：
文献类型：
--
作者：
Suguro, Toshiaki;Watanabe, Takuya;Adachi, Mitsuru
背景资料：人尾加压素II（U-II）是迄今为止发现的最有效的血管收缩肽，其循环血液水平在原发性高血压患者中升高。我们以前的研究表明，U-II加速人巨噬细胞泡沫细胞的形成和血管平滑肌细胞增殖，提示动脉粥样硬化斑块的发展。方法：测定50例高血压患者和31例正常血压对照者的颈动脉内膜-中层厚度（IMT）、斑块积分、血压、血浆U-Ⅱ水平和动脉粥样硬化参数。高血压患者的血浆U-II水平、最大IMT、斑块评分、收缩压和胰岛素抵抗的稳态模型评估（HOMA-IR）均显著高于正常血压对照组。年龄，性别。体重指数、高敏C反应蛋白（CRP）、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）、小密度脂蛋白胆固醇（LDL）、甘油三酯（TG）、脂蛋白（a）、胰岛素、空腹血糖水平两组间差异无统计学意义。所有受试者的血浆U-Ⅱ水平与收缩压、IMT、斑块积分、HOMA-IR均呈显著正相关，多元Logistic回归分析显示，血浆U-Ⅱ水平与颈动脉斑块的形成有关，（斑块评分>= 1.1）仍显著高于已确定的危险因素，如年龄，收缩压，高敏CRP，结论：我们的研究结果表明，在高血压患者的颈动脉粥样硬化的发展中，U-II水平的增加可能起着至关重要的作用。美国高血压杂志2007;20：211-217（c）2007年美国高血压杂志，有限公司。
Background: Circulating blood levels of human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, are increased in patients with essential hypertension. Our previous studies showed that U-II accelerates human macrophage foam cell formation and vascular smooth muscle cell proliferation, suggesting development of atherosclerotic plaque. In this study, we demonstrated a correlation between plasma U-II level and progression of atherosclerosis in hypertensive patients.Methods: The intima-media thickness (IMT) and plaque score in the carotid artery, blood pressure (BP), plasma levels of U-II, and atherosclerotic parameters were determined in 50 hypertensive patients and 31 normotensive controls.Results: Plasma U-II level, maximum IMT, plaque score, systolic BP, and homeostasis model assessment for insulin resistance (HOMA-IR) were significantly greater in hypertensive patients than normotensive controls. Age, gender. body mass index, and serum levels of high-sensitive C-reactive protein (CRP), HDL and LDL cholesterols, small dense LDL, triglycerides, lipoprotein(a), insulin, and fasting plasma glucose level were not significantly different between the two groups. In all subjects, plasma U-II level showed significant positive correlations with systolic BP, maximum IMT, plaque score, and HOMA-IR. Multiple logistic regression analysis indicated that the contribution of plasma U-II levels to carotid plaque formation (plaque score >= 1.1) was significantly still greater with a 60% increase than those of established risk factors, such as age, systolic BP, high-sensitive CRP, small dense LDL, and HOMA-IR.Conclusions: Our results suggest that increased levels of U-II may play a crucial role in the development of carotid atherosclerosis in hypertensive patients. Am J Hypertens 2007;20:211-217 (c) 2007 American Journal of Hypertension, Ltd.