NPY/AgRP neurons are not essential for feeding responses to glucoprivation
NPY/AgRP neurons are not essential for feeding responses to glucoprivation
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DOI：
10.1016/j.peptides.2006.08.036
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发表时间：
2007-02-01
期刊：
影响因子：
3
通讯作者：
Palmiter, Richard D.
中科院分区：
文献类型：
--
作者：
Luquet, Serge;Phillips, Colin T.;Palmiter, Richard D.
动物对低血糖的反应是进食和刺激新生血管的生成。这些对葡萄糖剥夺的反应是由大脑中的葡萄糖感知神经元发起的，但是控制进食行为的神经回路还没有很好地建立起来。下丘脑弓状区表达神经肽Y（NPY）和刺豚鼠相关蛋白（AgRP）的神经元参与介导对葡萄糖缺乏的摄食反应。我们设计了一种方法来选择性地消融新生小鼠的这些神经元，然后测试成年小鼠对禁食、轻度低血糖、2-脱氧-D-葡萄糖和生长激素释放肽受体激动剂的摄食反应。尽管对生长素释放肽受体激动剂的摄食反应被完全消除，但对葡萄糖缺乏的摄食反应是正常的。当有标准食物时，禁食后的摄食反应减弱，但当有更可口的固体或液体饮食时，摄食反应正常。我们的结论是，NPY/AgRP神经元是不必要的产生或介导的食欲对葡萄糖缺乏的反应，但他们是必不可少的饥饿素的喂养反应和再喂养标准的食物后，快速。(c)2007年爱思唯尔公司All rights reserved.
Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related protein (AgRP) have been implicated in mediating the feeding response to glucoprivation. We devised a method to selectively ablate these neurons in neonatal mice and then tested adult mice for their feeding responses to fasting, mild hypoglycemia, 2-deOXY-D-glucose and a ghrelin receptor agonist. Whereas the feeding response to the ghrelin receptor agonist was completely abrogated, the feeding response to glucoprivation was normal. The feeding response after a fast was attenuated when standard chow was available but normal with more palatable solid or liquid diet. We conclude that NPY/AgRP neurons are not necessary for generating or mediating the orexigenic response to glucose deficiency, but they are essential for the feeding response to ghrelin and refeeding on standard chow after a fast. (c) 2007 Elsevier Inc. All rights reserved.