Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women.
Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women.
复制标题
成功的 6 个月耐力训练不会改变健康老年男性和女性的胰岛素样生长因子-I。
DOI：
10.1093/gerona/52a.3.m149
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Schwartz,RS
中科院分区：
文献类型：
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作者：
Vitiello,MV;Wilkinson,CW;Merriam,GR;Moe,KE;Prinz,PN;Ralph,DD;Colasurdo,EA;Schwartz,RS
背景瘦体重、力量和耐力随着年龄的增长而下降，这些变化伴随着合成代谢激素的下降，包括生长激素（GH）和胰岛素样生长因子-I（IGF-I）。急性运动已被证明可以刺激GH/IGF-I轴，长期运动可以增加GH。本研究旨在探讨耐力训练对健康老年男性和女性IGF-I的影响。31名健康老年男性（66.9 ± 1.0岁，平均值± SEM）和21名健康老年女性（67.1 ± 1.7岁）被随机分配至3d/周、6个月耐力（ET 3）或伸展/柔韧性（SF 3）方案。另一组15名健康老年男性（69.0 ± 1.3岁）参加了一个更密集的5天/周，6个月的耐力协议（ET 5）。在训练前后，受试者体重稳定，并参加最大运动耐量测试、身体成分评估和空腹采血。ET 3训练导致最大有氧功率（V ~（02）max）显著增加（14%），体重（BW）、脂肪质量（FM）和腰臀比（WHR）显著降低，而去脂肪质量（FFM）显著增加。SF 3组中未观察到显著的V_（02）max或身体组成变化。对于ET 5组，观察到V ~（02）max显著增加（22%），BW、FM和WHR显著降低。三组中均未观察到IGF-I的显著变化。受试者训练前与训练后IGF-I值非常稳定（r= 0.86，p <0.001）。健康老年人的IGF-I基础水平在训练前和训练后评估之间非常稳定。两个耐力训练方案的幅度足以显着增加有氧能力和减少身体肥胖的措施没有显着增加基础水平的IGF-I在健康的老年男性和女性。
Background. Lean body mass, strength, and endurance decline with advancing age, changes paralleled by declines in anabolic hormones, including growth hormone (GH) and insulin-like growth factor-I (IGF-I). Acute exercise has been shown to stimulate the GH/IGF-I axis, and long-term exercise increases GH. This study examined the effect of endurance training on IGF-I in healthy older men and women.Methods. Thirty-one healthy older men (66.9 ± 1.0 yrs, mean ± SEM) and 21 healthy older women (67.1 ± 1.7 yrs) were randomized to either 3d/wk, 6-month endurance (ET3) or stretching/flexibility (SF3) protocols. Another group of 15 healthy older men (69.0 ± 1.3 yrs) participated in a more intensive 5d/wk, 6-month endurance protocol (ET5). Before and after training, subjects were weight stabilized and participated in maximal exercise tolerance testing, body composition assessment, and fasting blood sampling.Results. ET3 training resulted in a significant increase (14%) in maximal aerobic power (V̇02max), significant decreases in body weight (BW), fat mass (FM), and waist/hip ratio (WHR), and a significant increase in fat-free mass (FFM). No significant V̇02max or body composition changes were observed in the SF3 group. For the ET5 group, a significant increase (22%) in V̇02max and significant decreases in BW, FM, and WHR were observed. No significant changes in IGF-I were observed for any of the three groups. Pre- versus post-training IGF-I values were very stable (r= .86,p< .001) across subjects.Conclusions. Within-subject basal levels of IGF-I in healthy seniors were extremely stable between pre- and posttraining assessments. Two endurance training protocols of magnitudes sufficient to significantly increase aerobic capacity and decrease measures of body adiposity did not significantly increase basal levels of IGF-I in healthy older men and women.