When PRRs collide: mincle meddles with dectin and toll.
When PRRs collide: mincle meddles with dectin and toll.
复制标题
DOI：
10.1016/j.chom.2014.03.013
复制
发表时间：
2014-04
影响因子：
30.3
通讯作者：
A. Rivera
中科院分区：
文献类型：
--
作者：
A. Rivera
Pattern recognition receptors (PRR) promote pathogen eradication and shape adaptive immunity. Although evidence suggests PRRs can antagonize each other, few detailed mechanisms are known. Wevers et al. (2014) uncover a mechanism of PRR antagonism where fungal-induced Mincle signaling suppresses IL-12 transcription induced by other PRRs and thereby abates antifungal immunity.
