Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis.
Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis.
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Survivin在结直肠癌中的预后和临床病理学意义：一项荟萃分析。
DOI：
10.1371/journal.pone.0065338
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Knoefel WT
中科院分区：
文献类型：
--
作者：
Krieg A;Werner TA;Verde PE;Stoecklein NH;Knoefel WT
Survivin/BIRC 5是结直肠癌（CRC）的潜在预后标志物和治疗靶点。然而，有关CRC中生存素表达的现有数据是不一致的。因此，为了阐明生存素在结直肠癌患者中的预后相关性及其与临床病理参数的相关性，我们进行了荟萃分析。我们在PubMed和EMBASE中筛选了那些研究生存素的预后价值及其与结直肠癌临床病理参数相关性的研究。从合格的研究中提取数据，并使用随机效应模型纳入荟萃分析。电子文献检索确定了15项研究，包括1934例CRC患者，主要通过免疫组织化学（IHC）检测生存素。11项进行生存分析的研究的合并风险比显示，生存素表达与不良预后呈正相关（HR 1.93; 95%CI：1.55-2.42; P<0.00001; I2 = 23%）。 关于检测方法、HR估计、全球质量评分和研究来源国的亚组分析支持了这一观察结果的稳定性。此外，荟萃分析显示生存素表达与淋巴结转移（OR：0.37; 95%CI：0.19-0.75; I2 = 61%）或血管浸润（OR：0.50; 95%CI：0.28-0.90; I2 = 0%）之间存在显著相关性。 生存素的表达表明预后不良和促转移表型，并可能有助于确定一个亚组的患者，可以受益于针对生存素的靶向治疗CRC。
Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin expression in CRC are heterogeneous. Thus, to clarify the prognostic relevance of survivin in patients with CRC and its association with clinicopathological parameters we performed a meta-analysis. We screened PubMed and EMBASE for those studies that investigated the prognostic value of survivin and its association with clinicopathological parameters in CRC. Data from eligible studies were extracted and included into the meta-analyses using a random effects model. Electronical literature search identified 15 studies including 1934 patients with CRC mostly detecting survivin by immunohistochemistry (IHC). Pooled hazard ratios of 11 studies that performed survival analysis revealed a positive correlation between survivin expression and poor prognosis (HR 1.93; 95% CI: 1.55–2.42; P<0.00001; I2 = 23%). Subgroup analyses with respect to the detection method, HR estimation, global quality score and the country of origin in which the study was conducted supported the stability of this observation. In addition, meta-analyses revealed a significant association between expression of survivin and the presence of lymph node metastases (OR: 0.37; 95% CI: 0.19–0.75; I2 = 61%) or blood vessel invasion (OR: 0.50; 95% CI: 0.28–0.90; I2 = 0%). Expression of survivin indicates poor prognosis and a pro-metastatic phenotype and may be useful in identifying a subgroup of patients that could benefit from a targeted therapy against survivin in CRC.
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影响因子：
3.7
作者：
Hori M;Miki T;Okamoto M;Yazama F;Konishi H;Kaneko H;Shimamoto F;Ota T;Temme A;Tatsuka M
通讯作者：
Tatsuka M
影响因子：
11.5
作者：
Idenoue, S;Hirohashi, Y;Sato, N
通讯作者：
Sato, N
影响因子：
--
作者：
Lee, Ying-Yu;Yu, Cheng-Ping;Jin, Jong-Shiaw
通讯作者：
Jin, Jong-Shiaw
影响因子：
4.8
作者：
Dohi, T;Okada, K;Altieri, DC
通讯作者：
Altieri, DC
胃癌中不同生存变异的表达：源于苏属-2b在肿瘤进展中的作用的第一线索。
影响因子：
8.8
作者：
Krieg, A;Mahotka, C;Krieg, T;Grabsch, H;Muller, W;Takeno, S;Suschek, C V;Heydthausen, M;Gabbert, H E;Gerharz, C D
通讯作者：
Gerharz, C D