Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China.
Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae strains isolated from China.
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DOI：
10.1038/emi.2015.69
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发表时间：
2015-11
影响因子：
13.2
通讯作者：
Tan C
中科院分区：
文献类型：
--
作者：
Ding Y;Zhu D;Zhang J;Yang L;Wang X;Chen H;Tan C
本研究的目的是了解中国猪丹毒丝菌的流行病学、血清型、抗生素敏感性和克隆结构。2012年至2013年期间，从7个省份收集了48株菌株。脉冲场电泳鉴定出32种不同的模式，将其分为克隆群A-D。大多数脉冲场凝胶电泳（PFGE）模式中观察到的克隆复合体A和B，这表明在这两个占主导地位的克隆复合体的遗传特性的高度多样性。药敏试验结果显示，所有菌株对氨苄西林、红霉素、头孢噻肟敏感，对卡那霉素、头孢唑啉、磺胺嘧啶、丁胺卡那霉素耐药。红霉素和氨苄青霉素是治疗大肠埃希菌的首选抗生素。Rhusiopathiae. PFGE图谱在各主要无性系类群间的变异较大，表明E.中国的Rhusiopathiae可能起源于不同的谱系和来源，而不是一个单一的克隆谱系在不同地区的扩张。
The aim of this study was to understand the epidemiology, serotype, antibiotic sensitivity, and clonal structure of Erysipelothrix rhusiopathiae strains in China. Forty-eight strains were collected from seven provinces during the period from 2012 to 2013. Pulse-field electrophoresis identified 32 different patterns which were classified into clonal groups A–D. Most pulsed-field gel electrophoresis (PFGE) patterns were observed in clonal complex A and B, suggesting high diversity of genetic characterization in these two predominant clonal complexes. Antibiotic sensitivity test shows that all the stains were susceptible to ampicillin, erythromycin, and cefotaxime, and resistant to kanamycin, cefazolin, sulfadiazine, and amikacin. Erythromycin and ampicillin are recommended as first-line antibiotics for treatment of E. rhusiopathiae in China. The high variation in PFGE pattern among the main clonal groups shows that the E. rhusiopathiae in China may originate from different lineages and sources instead of from expansion of a single clonal lineage across different regions.