A Method for Inferring an Individual's Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations.
A Method for Inferring an Individual's Genetic Ancestry and Degree of Admixture Associated with Six Major Continental Populations.
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DOI：
10.3389/fgene.2012.00322
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发表时间：
2012
影响因子：
3.7
通讯作者：
Schork NJ
中科院分区：
文献类型：
--
作者：
Libiger O;Schork NJ
在遗传和一般流行病学研究中，确定受试者的祖先和遗传背景是分析相关结果或关联的关键组成部分。虽然有许多方法可以根据遗传标记区分个体之间的祖先亚群，但这些方法中只有少数提供了可能与不同祖先群体相关的个体基因组部分的实际估计。我们提出了一种方法，用于分配祖先，工程分阶段细化估计祖先人口的贡献，个人基因组。该方法利用了从具有已知祖先的个体获得的公共领域中的基因型数据。虽然我们展示的方法在评估祖先基因组的比例，主要是利用大陆人口，该战略可用于评估内大陆或更微妙的祖先起源与适当的数据。
The determination of the ancestry and genetic backgrounds of the subjects in genetic and general epidemiology studies is a crucial component in the analysis of relevant outcomes or associations. Although there are many methods for differentiating ancestral subgroups among individuals based on genetic markers only a few of these methods provide actual estimates of the fraction of an individual’s genome that is likely to be associated with different ancestral populations. We propose a method for assigning ancestry that works in stages to refine estimates of ancestral population contributions to individual genomes. The method leverages genotype data in the public domain obtained from individuals with known ancestries. Although we showcase the method in the assessment of ancestral genome proportions leveraging largely continental populations, the strategy can be used for assessing within-continent or more subtle ancestral origins with the appropriate data.