L-methionine decreases dendritic spine density in mouse frontal cortex.
L-methionine decreases dendritic spine density in mouse frontal cortex.
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DOI：
10.1097/wnr.0b013e3283373126
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发表时间：
2010-06-02
期刊：
影响因子：
1.7
通讯作者：
Costa E
中科院分区：
文献类型：
--
作者：
Tueting P;Davis JM;Veldic M;Pibiri F;Kadriu B;Guidotti A;Costa E
Schizophrenia postmortem brain is characterized by GABAergic downregulation and by decreased dendritic spine density in frontal cortex. Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our previous work (Tremolizzo et al. and Dong et al.) has shown that L-methionine decreases reelin and GAD67 transcription in mice which is prevented by co-administration of valproate. In this study, we observed a decrease in spine density following L-methionine treatment, which was prevented by co-administration of valproate. Together with our previous findings conducted under the same experimental conditions, we suggest that downregulation of spine density in L-methionine -treated mice may be due to decreased expression of reelin and that valproate may prevent spine downregulation by inhibiting the methylation induced decrease in reelin.
