Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients
Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients
复制标题
肿瘤基质中 CD68( ) 肿瘤相关巨噬细胞的微定位与口腔鳞状细胞癌患者不良临床结果相关
DOI：
10.1007/s13277-015-3189-5
复制
发表时间：
2015-07-01
期刊：
影响因子：
--
通讯作者：
Hou, Ya-Yi
中科院分区：
文献类型：
--
作者：
Ni, Yan-Hong;Ding, Liang;Hou, Ya-Yi
CD68作为肿瘤相关巨噬细胞（TAM）的泛巨噬细胞标志物已被广泛应用于肿瘤相关巨噬细胞的癌变过程中。但CD68(+) TAMs与患者预后的相关性并不一致，这可能是由于缺乏特异性的TAMs标志物所致。我们发现CD68(+) tam的微定位在口腔鳞状细胞癌（OSCC）患者的预后中也发挥了独特的作用。应用免疫组织化学方法在91例石蜡包埋的OSCC标本中鉴定出CD68(+) tam。CD68(+) TAMs的数量从邻近的非瘤组织（NT）到瘤巢（TN）明显增加，但CD68(+) TAMs浸润肿瘤间质（TS）的频率最高(P
CD68 has been widely used as a pan-macrophage marker for tumor-associated macrophages (TAM) which always involve in carcinogenesis. But the correlations between CD68(+) TAMs and prognosis of patients show to be inconsistent, which might due to lack of specific markers of TAMs. We here found that the microlocalization of CD68(+) TAMs also played a unique role in prognosis of patients with oral squamous cell carcinoma (OSCC). CD68(+) TAMs were identified in paraffin-embedded OSCC specimens (n=91) by using immunohistochemistry. The number of CD68(+) TAMs was remarkably increased from adjacent none-neoplasia tissues (NT) to tumor nest (TN), but tumor stroma (TS) was infiltrated with highest frequency of CD68(+) TAMs (P