Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software
Retinal thickness in healthy and diabetic subjects measured using optical coherence tomography mapping software
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DOI：
10.1177/112067210201200205
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发表时间：
2002-03-01
影响因子：
1.7
通讯作者：
Gaudric, A
中科院分区：
文献类型：
--
作者：
Massin, P;Erginay, A;Gaudric, A
目的。使用光学相干断层扫描 (OCT) 绘图软件定义健康受试者的正常视网膜厚度，并评估 OCT 检测糖尿病患者早期黄斑增厚的能力。方法。对 60 只健康眼睛和 35 名在生物显微镜下没有黄斑水肿的糖尿病患者的 70 只眼睛进行了以注视点为中心的 6 次放射状扫描。使用 OCT 绘图软件自动测量视网膜厚度。根据年龄、性别和眼睛，比较健康患者亚组以及糖尿病患者和健康受试者的眼睛的平均视网膜厚度。如果某个区域的平均视网膜厚度大于健康受试者相应区域的平均厚度+2SD，则诊断为增厚；或者如果右眼和左眼之间的差异超过健康受试者给定区域的平均差异 + 2 SD。结果。在健康受试者中，直径为 1000 微米的中央黄斑区域的平均视网膜厚度为 170 +/- 18 微米。根据年龄或左眼或右眼的不同，没有显着差异，但男性黄斑中心厚度显着大于女性（p=0.0139）。在生物显微镜下，健康受试者和无黄斑水肿的糖尿病患者的眼睛没有观察到差异，但 OCT 在 12 只糖尿病眼中检测到早期黄斑增厚。结论。在这项研究中，使用市售绘图软件定义了正常人群的平均视网膜厚度和平均局部变化。 OCT 似乎是检测早期视网膜增厚的敏感工具。
PURPOSE. To define the normal retinal thickness in healthy subjects using optical coherence tomography (OCT) mapping software and to assess the ability of OCT to detect early macular thickening in diabetic patients.METHODS. Six radial scans centered on the fixation point were done on 60 healthy eyes and 70 eyes of 35 diabetic patients without macular edema on biomicroscopy. Retinal thickness was measured automatically with OCT mapping software. Mean retinal thickness was compared in subgroups of healthy patients based on age, sex, and eye, and in the eyes of diabetic patients and healthy subjects. Thickening was diagnosed if mean retinal thickness of an area was greater than the mean thickness + 2SD in the corresponding area in healthy subjects; or if the difference between right and left eye exceeded the mean difference + 2 SD in a given area in healthy subjects.RESULTS. In healthy subjects, mean retinal thickness in the central macular area 1000 mum in diameter was 170 +/- 18 mum. There was no significant difference according to age, or left or right eye, but central macular thickness was significantly greater in men than women (p=0.0139). No difference was observed between the eyes of healthy subjects and diabetic patients without macular edema on biomicroscopy, but OCT detected early macular thickening in 12 diabetic eyes.CONCLUSIONS. In this study average retinal thickness and mean local variations in a normal population were defined using a commercially available mapping software. OCT seems a sensitive tool for detecting early retinal thickening.