The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract
The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract
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DOI：
10.1159/000086596
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发表时间：
2005-01-01
影响因子：
2.1
通讯作者：
Löfgren, S
中科院分区：
文献类型：
--
作者：
Dong, XQ;Söderberg, PG;Löfgren, S
研究了暴露时间对避免紫外线辐射 B (UVRB) 诱发白内障的最大可接受剂量 (MAD) 的影响。 Sprague-Dawley 大鼠被分为 5 个暴露时间组：7.5、15、30、60 和 120 分钟。每个暴露时间组分为5个剂量亚组：0、1、2、4和8 kJ/m(2)。将大鼠单侧暴露于 300 nm 左右的 UVR。曝光一周后，记录宏观结构并测量透镜前向光散射。根据剂量反应函数估计避免 UVRB 诱发白内障的 MAD。 7.5、15、30、60 和 120 分钟暴露时间下避免 UVRB 诱发白内障的 MAD 估计分别为 2.0、1.4、1.9、1.8 和 2.2 kJ/m(2)。在 7.5 - 120 分钟的曝光时间范围内，避免 UVRB 诱发的白内障的 MAD 取决于曝光时间。版权所有 (C) 2005 S. Karger AG，巴塞尔。
The effect of exposure time on maximum acceptable dose ( MAD) for avoidance of ultraviolet radiation B (UVRB)-induced cataract was investigated. Sprague-Dawley rats were divided into 5 exposure time groups: 7.5, 15, 30, 60, and 120 min. Each exposure time group was divided into 5 dose subgroups: 0, 1, 2, 4, and 8 kJ/m(2). The rats were unilaterally exposed to UVR around 300 nm. One week after the exposure, macroscopic structure was recorded and lens forward light scattering was measured. MAD for avoidance of UVRB-induced cataract was estimated based on the dose-response function. MAD for avoidance of UVRB-induced cataract for 7.5, 15, 30, 60, and 120 min exposures was estimated to be 2.0, 1.4, 1.9, 1.8 and 2.2 kJ/m(2), respectively. In the exposure time domain 7.5 - 120 min, MAD for avoidance of UVRB-induced cataract depends on exposure time. Copyright (C) 2005 S. Karger AG, Basel.