Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms
Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms
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DOI：
10.1053/euhj.1999.1873
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发表时间：
2000-06-01
影响因子：
39.3
通讯作者：
Channer, KS
中科院分区：
文献类型：
--
作者：
English, KM;Mandour, O;Channer, KS
目的高雄激素水平被许多人推定为解释男性易患冠状动脉疾病的原因。然而，天然雄激素抑制男性动脉粥样硬化([1]。)方法和结果90例男性受试者(冠状动脉造影阳性者60例，阴性者30例)入选研究对象。清晨，从每个患者身上采集空腹血样，并测定游离、总和生物可利用的睾酮、性激素结合球蛋白、雌二醇和血脂。生物可利用型睾酮的测定采用一种改进的技术。计算游离雄激素指数。冠心病组游离睾酮水平显著低于对照组(P=0.027)，游离睾酮水平显著低于正常对照组(P=0.005)，游离雄激素指数显著低于对照组(P=0.005)。在控制了年龄和体重指数的差异后，游离雄激素指数和生物可利用睾酮水平的差异仍有统计学意义(分别为P=0.008和P=0.013)。结论冠心病患者的雄激素水平显著低于正常对照组，挑战了男性生理性高雄激素水平导致冠状动脉疾病相对风险增加的传统观念。(欧洲心脏病杂志2000；21：890-894)(C)2000欧洲心脏病学会。
Aims High androgen levels are presumed by many to explain the male predisposition to coronary artery disease. However, natural androgens inhibit male atherosclerosis([1].) Our aim was to determine whether levels of androgens differ between men with and without coronary artery disease.Methods and Results Ninety male subjects (60 with positive, and 30 with negative coronary angiograms) were recruited. Early morning, fasting blood samples were taken from each patient and free, total and bioavailable testosterone, sex hormone binding globulin, oestradiol, and lipids were measured. Bioavailable testosterone was assayed using a modified technique. Free androgen index was calculated. Men with coronary artery disease had significantly lower levels of free testosterone (mean (standard deviation)); 47.95 (13.77) vs 59.87 (26.05)pmol.l(-1), P=0.027), bioavailable testosterone; 2.55(0.77) vs 3.26 (1.18) nmol.l(-1), P=0.005 and free androgen index; 37.8 (10.4) vs 48.47 (18.3), P=0.005, than controls. After controlling for differences in age and body mass index the differences in free androgen index and bioavailable testosterone remained statistically significant (P=0.008 and P=0.013, respectively).Conclusion Men with coronary artery disease have significantly lower levels of androgens than normal controls, challenging the preconception that physiologically high levels of androgens in men account for their increased relative risk for coronary artery disease. (Eur Heart J 2000; 21: 890-894) (C) 2000 The European Society of Cardiology.