The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice.
The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice.
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DOI：
10.1016/0041-008x(80)90202-1
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发表时间：
1980-06
影响因子：
3.8
通讯作者：
C. Snyder;B. Goldstein;A. Sellakumar;Isabel Bromberg;S. Laskin;Roy E. Albert
中科院分区：
文献类型：
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作者：
C. Snyder;B. Goldstein;A. Sellakumar;Isabel Bromberg;S. Laskin;Roy E. Albert
AKR J小鼠和C57BL 6J小鼠分别终生暴露于100和300 ppm苯。在整个暴露过程中，每两周采集一次外周血细胞计数。苯暴露的AKR小鼠产生贫血和淋巴细胞减少。20%的暴露AKR小鼠出现骨髓发育不全，而对照组为2%。苯暴露不会改变AKR小鼠中常见的病毒诱导淋巴瘤的发生率或诱导时间。在C57 BL小鼠中，暴露于苯产生贫血，淋巴细胞减少症，嗜中性粒细胞伴随着左移。13只（33%）暴露的C57 BL小鼠出现骨髓增生，其中4只小鼠的增生基本上限于粒细胞生成元素。对照C57BL小鼠均未发生骨髓增生。在苯暴露的C57BL小鼠中，造血系统肿瘤的发病率显着增加，包括6例（15%）胸腺淋巴瘤。虽然两个对照组小鼠（5%）死于淋巴瘤，但这些肿瘤均不涉及胸腺。胸腺淋巴瘤在C57 BL小鼠中很少见，但可由电离辐射和化学致癌物引起。
AKR J mice and C57BL 6J mice were given lifetime exposures to 100 and 300 ppm benzene, respectively. Peripheral blood cell counts were obtained biweekly throughout the exposures. Anemia and lymphocytopenia were produced in benzene-exposed AKR mice. Twenty percent of the exposed AKR mice developed bone marrow hypoplasia, compared to 2% for the controls. The benzene exposures did not alter the incidence or induction time of the viral-induced lymphomas commonly seen in AKR mice. In C57BL mice, exposure to benzene produced anemia, lymphocytopenia, and neutrophilia accompanied by a left shift. Thirteen (33%) of the exposed C57BL mice developed bone marrow hyperplasia and in four of these mice, hyperplasia was essentially limited to granulopoietic elements. None of the control C57BL mice developed bone marrow hyperplasia. In benzene-exposed C57BL mice there was a significant increase in the incidence of hematopoietic neoplasms including six cases (15%) of thymic lymphoma. Although two control mice (5%) died with lymphoma neither of these tumors involved the thymus. Thymic lymphoma is rare in C57BL mice but can be produced by ionizing radiation and chemical carcinogens.