Effects of glucagon on cardiac chronotropic response to vagal stimulation in the dog.
Effects of glucagon on cardiac chronotropic response to vagal stimulation in the dog.
复制标题
胰高血糖素对狗迷走神经刺激的心脏变时性反应的影响。
DOI：
10.1152/ajpheart.1982.242.1.h7
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Zieske,H
中科院分区：
文献类型：
--
作者：
Stuesse,SL;Levy,MN;Zieske,H
胰高血糖素不依赖于交感神经系统的刺激而加速心脏。在开胸麻醉犬上，观察了高血糖素对反复迷走神经刺激的变时性反应的影响。当以恒定频率刺激颈迷走神经时，给予胰高血糖素不影响心率的变化，即没有明显的迷走神经松解作用。因此，高血糖素不会改变乙酰胆碱与心脏突触后受体的反应。当在每个心动周期间歇刺激迷走神经时，产生的心跳周期取决于迷走神经刺激传递的时间。胰高血糖素减少了迷走神经时相性刺激所获得的最大和最小心动周期长度。正如之前已经证明的那样，迷走神经对心脏的冲动往往在心脏周期的特定时间内聚集在一起，通过加速心脏，胰高血糖素可能会改变心脏对迷走神经刺激的反应。
Glucagon accelerates the heart independent of sympathetic nervous system stimulation. The effect of glucagon on the chronotropic responses to repetitive bursts of vagal stimulation was determined in open-chest anesthesized dogs. When the cervical vagi were stimulated at constant frequencies, the change in heart rate was not affected by glucagon administration, i.e., no vagolytic effect caused by glucagon was apparent. Thus glucagon did not alter the reaction of acetylcholine with cardiac postsynaptic receptors. When the vagi were stimulated intermittently with one short burst of vagal stimuli delivered each cardiac cycle, the resultant heart period was dependent on the time of vagal stimulus delivery. Both maximum and minimum cardiac cycle lengths obtained during phasic vagal stimulation were decreased by glucagon. As it has been previously demonstrated that vagal impulses to the heart tend to be clustered during certain times of the cardiac cycle, by accelerating the heart glucagon may shift the cardiac response to vagal stimulation.