Brain response to taste in overweight children: A pilot feasibility study
Brain response to taste in overweight children: A pilot feasibility study
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DOI：
10.1371/journal.pone.0172604
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发表时间：
2017-02-24
期刊：
影响因子：
3.7
通讯作者：
Bohon, Cara
中科院分区：
文献类型：
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作者：
Bohon, Cara
了解儿童在体重增加的早期阶段对食物和食物暗示的神经反应可能有助于我们确定不健康饮食行为和肥胖风险所涉及的驱动过程。在预期和接受巧克力奶昔口味的同时，6-8岁的健康体重和超重儿童(N=18；10名BMI在5%到85%之间的儿童和8名BMI和GT；85%的ILE儿童)接受了fMRI扫描。家长们填写了一份儿童饮食行为问卷。结果显示，超重儿童在右侧脑岛、脑盖、中央前回和角回，以及双侧楔前和扣带后，对奶昔味觉的反应更强。在大脑对视觉食物提示的反应方面，没有发现组内差异。探索性分析揭示了自我报告饮食行为和体重状况对大脑对味道的反应之间的相互作用。这项初步研究为研究幼儿味觉加工的可行性提供了初步证据，并提示大脑对味觉的反应可能发生了发展变化。
Understanding the neural response to food and food cues during early stages of weight gain in childhood may help us determine the drive processes involved in unhealthy eating behavior and risk for obesity. Healthy weight and overweight children ages 6-8 (N = 18; 10 with BMI between 5 th and 85 th % ile and 8 with BMI > 85 th % ile) underwent fMRI scans while anticipating and receiving tastes of chocolate milkshake. Parents completed a Children's Eating Behaviour Questionnaire. Results reveal greater response to milkshake taste receipt in overweight children in the right insula, operculum, precentral gyrus, and angular gyrus, and bilateral precuneus and posterior cingulate. No group differences were found for brain response to a visual food cue. Exploratory analyses revealed interactions between self-report measures of eating behavior and weight status on brain response to taste. This pilot study provides preliminary evidence of feasibility of studying young children's taste processing and suggests a possible developmental shift in brain response to taste.