Tangential migration of luteinizing hormone-releasing hormone (LHRH) neurons in the medial telencephalon in association with transient axons extending from the olfactory nerve.
Tangential migration of luteinizing hormone-releasing hormone (LHRH) neurons in the medial telencephalon in association with transient axons extending from the olfactory nerve.
复制标题
内侧端脑中黄体生成素释放激素（LHRH）神经元的切向迁移与从嗅觉神经延伸的瞬时轴突相关。
DOI：
10.1016/0304-3940(95)12210-9
复制
发表时间：
1995
影响因子：
2.5
通讯作者：
Fritzsch,B
中科院分区：
文献类型：
--
作者：
NorgrenJr,RB;Gao,C;Ji,Y;Fritzsch,B
在胚胎发育过程中，促黄体生成激素释放激素（LHRH）神经元通过嗅神经从内侧嗅上皮迁移到大脑。LHRH神经元进入大脑，并沿端脑内侧边缘切向沿着迁移，与富含神经细胞粘附分子（N-CAM）的纤维束密切相关。在目前的工作中，我们希望确定这种富含N-CAM的纤维束是否是嗅神经的延伸。消融实验，免疫细胞化学和diI植入物都表明，LHRH神经元迁移与一个非常小的子集的短暂的N-CAM丰富的神经元过程，延伸出适当的隔视前区的嗅神经。
During embryonic development, luteinizing hormone-releasing hormone (LHRH) neurons migrate to the brain from the medial olfactory epithelium through the olfactory nerve. LHRH neurons enter the brain and migrate tangentially along the medial edge of the telencephalon in close association with a neural cell adhesion molecule (N-CAM) enriched fiber bundle. In the current work we wished to determine whether this N-CAM enriched 'fiber bundle is an extension of the olfactory nerve. Ablation experiments, immunocytochemistry and diI implants all suggest that LHRH neurons migrate in association with a very small subset of transient N-CAM enriched neuronal processes which, extend out of the olfactory nerve proper to the septal-preoptic area.