Pharmaceutical Applications of Plasticized Polymers
Pharmaceutical Applications of Plasticized Polymers
复制标题
增塑聚合物的制药应用
DOI：
10.5772/36543
复制
发表时间：
2012
影响因子：
5.6
通讯作者：
M. Dittrich
中科院分区：
文献类型：
--
作者：
E. Šnejdrová;M. Dittrich
如果没有增塑聚合物，现代制药技术是不可想象的。聚合物的制药应用范围从常规剂型的包装材料或辅助物质到改变和控制治疗系统中药物释放特性的膜或基质。最近，人们对多种增塑聚合物系统进行了研究，如微粒、基质、游离膜、透皮系统膜和原位形成植入物。对于药物输送系统所需的质量而言，不仅是聚合物本身，而且聚合物系统的其他成分的彻底选择也是必要的。增塑剂因其主要作用，在药物聚合物体系中具有不可替代的地位。 e.通过降低玻璃化转变温度来提高聚合物的柔韧性和加工性能。特定增塑聚合物药物递送系统的超分子结构和相关性质引起了许多研究人员的兴趣。
The modern pharmaceutical technology is not conceivable without plasticized polymers. The pharmaceutical applications of polymers range from packaging materials or auxiliary substances in conventional dosage forms to membranes or matrices modifying and controlling the drug release characteristics in therapeutic systems. Recently, a great variety of plasticized polymeric systems have been studied as microparticles, matrices, free membranes, membranes for transdermal systems and in situ forming implants. Not only the polymer itself but thorough choice of other ingredients of the polymer system is necessary for required quality of drug delivery system. The plasticizer has the unsubstitutable place in drug polymer system due to its primary role, i. e. improve the flexibility and processability of polymers by lowering the glass transition temperature. The supramolecular structure and relevant properties of specific plasticized polymer drug delivery systems has attracted the interest of many researchers.
影响因子：
10.8
作者：
Solorio, Luis;Babin, Brett M.;Patel, Ravi B.;Mach, Justyna;Azar, Nami;Exner, Agata A.
通讯作者：
Exner, Agata A.
DOI：
10.1016/j.jconrel.2010.08.020
发表时间：
2010-11-01
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Patel RB;Solorio L;Wu H;Krupka T;Exner AA
通讯作者：
Exner AA