Toward a Database of Intracranial Electrophysiology during Natural Language Presentation.
Toward a Database of Intracranial Electrophysiology during Natural Language Presentation.
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DOI：
10.1080/23273798.2018.1500262
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发表时间：
2020
影响因子：
2.3
通讯作者：
Halgren, Eric
中科院分区：
文献类型：
--
作者：
Kaestner, Erik;Morgan, Adam Milton;Snider, Joseph;Zhan, Meilin;Jiang, Xi;Levy, Roger;Ferreira, Victor S;Thesen, Thomas;Halgren, Eric
使用认知任务的颅内电生理学（iEEG）研究有助于理解语言的神经基础。然而，尽管在临床治疗期间连续记录iEEG，但由于患者的考虑，任务时间有限。为了增加iEEG记录在语言研究中的有用性，我们为患者提供了一个预装有自然语言媒体的平板电脑，与临床iEEG无线同步。这种收集并时间锁定到自然语言呈现的iEEG数据特别适用于研究将单词组合到更大上下文中的神经基础。我们验证了这种方法与试点分析，涉及在电影中听到的话，标记句法属性和动词上下文概率。高频功率（70- 170 Hz）的事件相关平均值确定了双侧侧裂周电极对句法类别的不同反应，线性回归确定了与上下文概率相关的活动，证明了将媒体与iEEG对齐的有用性。我们设想未来的多站点合作建立一个“颅内神经语言语料库”。
Intracranial electrophysiology (iEEG) studies using cognitive tasks contribute to the understanding of the neural basis of language. However, though iEEG is recorded continuously during clinical treatment, due to patient considerations task time is limited. To increase the usefulness of iEEG recordings for language study, we provided patients with a tablet pre-loaded with media filled with natural language, wirelessly synchronized to clinical iEEG. This iEEG data collected and time-locked to natural language presentation is particularly applicable for studying the neural basis of combining words into larger contexts. We validate this approach with pilot analyses involving words heard during a movie, tagging syntactic properties and verb contextual probabilities. Event-related averages of high-frequency power (70–170Hz) identified bilateral perisylvian electrodes with differential responses to syntactic class and a linear regression identified activity associated with contextual probabilities, demonstrating the usefulness of aligning media to iEEG. We imagine future multi-site collaborations building an ‘intracranial neurolinguistic corpus’.