Transplantation of human prostatic carcinoma into nude mice in Matrigel.
Transplantation of human prostatic carcinoma into nude mice in Matrigel.
复制标题
DOI：
--
复制
发表时间：
1991-07
期刊：
影响因子：
11.2
通讯作者：
T. Pretlow;Carrie M. Delmoro;Ginny G. Dilley;Carmela G. Spadafora;T. P. Pretlow
中科院分区：
文献类型：
--
作者：
T. Pretlow;Carrie M. Delmoro;Ginny G. Dilley;Carmela G. Spadafora;T. P. Pretlow
以前成功的人原发性前列腺癌裸鼠移植被描述为“接近于零”。“当注射在Matrigel而不是培养基中时，在3个月的观察期间，裸鼠中肿瘤生长所需的PC-3人前列腺癌细胞系的细胞减少了25，000倍;在其他两种人前列腺癌细胞系中观察到类似的增强。以Matrigel为载体，10例原发性前列腺癌中有6例成功移植到裸鼠体内。
Previous successful transplantation of human primary prostatic carcinomas into nude mice has been described as "close to zero." When injected in Matrigel instead of culture medium, 25,000-fold fewer cells of the PC-3 human prostatic carcinoma cell line were required for the growth of tumors in nude mice during a 3-month period of observation; similar enhancement was observed with two other human prostatic carcinoma cell lines. Six of ten primary human prostatic carcinomas were transplanted successfully into nude mice when Matrigel was used as the vehicle.