Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women.
Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women.
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DOI：
10.2147/ijwh.s41884
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ongphiphadhanakul B
中科院分区：
文献类型：
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作者：
Namwongprom S;Rojanasthien S;Mangklabruks A;Soontrapa S;Wongboontan C;Ongphiphadhanakul B
本研究的目的是调查绝经后和围绝经期泰国妇女的脂肪量、瘦体重和骨密度（BMD）之间的关系。对1579名年龄在40-90岁之间的健康泰国妇女进行了一项横断面研究。全身，腰椎，股骨，股骨颈BMD和身体成分的双能X线吸收测量。为了评估脂肪量和瘦体重与BMD的各种测量之间的关联，使用多变量线性回归模型来估计脂肪量和瘦体重的回归系数，首先在单独的方程中，然后在同一方程中同时估计脂肪量和瘦体重。在研究人群中，1448例受试者（91.7%）为绝经后，131例（8.3%）为围绝经期。在绝经后妇女中，在控制了年龄、身高和绝经持续时间后，脂肪量和瘦体重与BMD呈正相关，当它们彼此独立分析时。当包括在同一方程中时，脂肪量和瘦体重都继续显示出积极的影响，但瘦体重对BMD的影响显著大于脂肪量，除了全身。在控制了围绝经期妇女的年龄和身高后，瘦体重而不是脂肪量对除腰椎外的所有骨骼部位的BMD有积极影响。瘦体重对绝经后和围绝经期妇女的BMD有显著的有益影响，可以被认为是骨量的决定因素之一。脂肪量的影响与绝经状态有关，但仅在围绝经期妇女中表现出积极的影响。
The purpose of this study was to investigate the association between fat mass, lean mass, and bone mineral density (BMD) in postmenopausal and perimenopausal Thai women. A cross-sectional study was conducted in 1579 healthy Thai women aged 40–90 years. Total body, lumbar spine, total femur, and femoral neck BMD and body composition were measured by dual x-ray absorptiometry. To evaluate the associations between fat mass and lean mass and various measures of BMD, multivariable linear regression models were used to estimate the regression coefficients for fat mass and lean mass, first in separate equations and then with both fat mass and lean mass in the same equation. Among the study population, 1448 subjects (91.7%) were postmenopausal and 131 (8.3%) were perimenopausal. In postmenopausal women, after controlling for age, height, and duration of menopause, both fat mass and lean mass were positively correlated with BMD when they were analyzed independently of each other. When included in the same equation, both fat mass and lean mass continued to show a positive effect, but lean mass had a significantly greater impact on BMD than fat mass at all regions except for total body. Lean mass but not fat mass had a positive effect on BMD at all skeletal sites except the lumbar spine, after controlling for age and height in perimenopausal women. Lean mass had a significant beneficial effect on BMD in both postmenopausal and perimenopausal women and can be considered as one of the determinants of bone mass. The effect of the fat mass was related to menopausal status, but only demonstrated a positive impact in perimenopausal women.