Identification of Staphylococcus xylosus Isolated from C57BL/6J‐Nos2tm1Lau Mice with Dermatitis
Identification of Staphylococcus xylosus Isolated from C57BL/6J‐Nos2tm1Lau Mice with Dermatitis
复制标题
DOI：
10.1111/j.1348-0421.2002.tb02744.x
复制
发表时间：
2002-09
影响因子：
2.6
通讯作者：
Young‐Suk Won;H. Kwon;Goo Taeg Oh;B. Kim;C. Lee;Y. Park;B. Hyun;Yang‐Kyu Choi
中科院分区：
文献类型：
--
作者：
Young‐Suk Won;H. Kwon;Goo Taeg Oh;B. Kim;C. Lee;Y. Park;B. Hyun;Yang‐Kyu Choi
凝固酶阴性葡萄球菌（CNS）是重要的病原体，特别是在医疗器械相关感染和免疫功能低下的患者中。从5只患有皮炎的NOS 2基因敲除小鼠中分离到5株CNS菌株。组织学上，在耳周皮肤发现肉芽肿性皮炎伴表皮溃疡。皮肤病变包括脓疱、坏死以及中性粒细胞和巨噬细胞积聚。通过API STAPH试剂盒和16 S-23 S基因间转录间隔区PCR鉴定细菌菌株的分离株为木糖葡萄球菌。这些结果表明该生物体有可能成为免疫功能低下小鼠中的机会病原体。
Coagulase negative staphylococci (CNS) are significant pathogens, particularly in medical device related infections and in immunocompromised patients. Five CNS strains were isolated from 5 NOS2 knockout mice with dermatitis. Histologically, granulomatous dermatitis was found in the skin around the ear with epidermal ulceration. Dermal lesions included pustules, necrosis, and accumulations of neutrophils and macrophages. Isolates of the bacterial strains were identified to be Staphylococcus xylosus by the API STAPH kit and 16S–23S intergenic transcribed spacer‐PCR. These results demonstrate the potential of this organism to be an opportunistic pathogen in immunocompromised mice.