Preeclampsia 2012.
Preeclampsia 2012.
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DOI：
10.1155/2012/586578
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发表时间：
2012
影响因子：
3.2
通讯作者：
Faulkner M
中科院分区：
文献类型：
--
作者：
Eiland E;Nzerue C;Faulkner M
先兆子痫是一种常见的妊娠并发症，与孕产妇高发病率和死亡率以及胎儿宫内生长受限有关。大量证据表明，该综合征中子宫胎盘血流量的减少是由缺氧、血管生成和抗血管生成因子失衡、炎症和免疫紊乱等毒性组合所致。接受先兆子痫治疗的女性患心血管和肾脏疾病的风险也会增加。目前尚不清楚心血管和肾脏疾病风险的增加是否是由于先兆子痫引起的内皮损伤的残留和/或进行性影响所致，或者是由于先兆子痫和心脏病之间共有的危险因素所致。此外，内皮素-1 信号传导似乎在与先兆子痫相关的高血压中发挥着核心作用。在本文中，我们讨论了有关先兆子痫发病机制的新数据并回顾了治疗方案。
Preeclampsia is a common complication of pregnancy associated with high maternal morbidity and mortality and intrauterine fetal growth restriction. There is extensive evidence that the reduction of uteroplacental blood flow in this syndrome results from the toxic combination of hypoxia, imbalance of angiogenic and antiangiogenic factors, inflammation, and deranged immunity. Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease. At present it is unclear if the increased cardiovascular and renal disease risks are due to residual and or progressive effects of endothelial damage from the preeclampsia or from shared risk factors between preeclampsia and cardiac disease. Moreover, it appears that endothelin-1 signaling may play a central role in the hypertension associated with preeclampsia. In this paper, we discuss emerging data on the pathogenesis of preeclampsia and review therapeutic options.