Spinal plasticity of acute opioid tolerance
Spinal plasticity of acute opioid tolerance
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DOI：
10.1159/000025449
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发表时间：
2000-05-01
影响因子：
11
通讯作者：
Wilcox, GL
中科院分区：
文献类型：
--
作者：
Fairbanks, CA;Wilcox, GL
脊髓急性阿片类药物耐受性的机制仍不充分。阿片类药物和其他镇痛药的直接脊髓给药的临床应用的扩大表明，进一步了解镇痛耐受的脊髓机制的研究是必要的。啮齿动物模型的脊髓管理促进这一目标。具体而言，小鼠的急性脊髓阿片类药物耐受性为评价新型临床药物提供了可塑性依赖性、快速和有效的机会。急性和慢性脊髓阿片耐受、神经性疼痛以及学习和记忆的药理学之间的相似性表明，该模型可以作为新型可塑性修饰化合物的生物活性的高通量预测因子。国家科学理事会版权所有（C）2000 Karger AG，巴塞尔。
Spinal acute opioid tolerance remains mechanistically undercharacterized. Expanded clinical use of direct spinal administration of opioids and other analgesics indicates that studies to further understand spinal mechanisms of analgesic tolerance are warranted. Rodent models of spinal administration facilitate this objective. Specifically, acute spinal opioid tolerance in mice presents a plasticity-dependent, rapid, and efficient opportunity for evaluation of novel clinical agents. Similarities between the pharmacology of acute and chronic spinal opioid tolerance, neuropathic pain, and learning and memory suggest that this model may serve as a high through-put predictor of bioactivity of novel plasticity-modifying compounds. Copyright (C) 2000 National Science Council, ROC and S. Karger AG, Basel.