GRAPHICAL EVALUATION OF BLOOD-TO-BRAIN TRANSFER CONSTANTS FROM MULTIPLE-TIME UPTAKE DATA
GRAPHICAL EVALUATION OF BLOOD-TO-BRAIN TRANSFER CONSTANTS FROM MULTIPLE-TIME UPTAKE DATA
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DOI：
10.1038/jcbfm.1983.1
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发表时间：
1983-01-01
影响因子：
6.3
通讯作者：
FENSTERMACHER, JD
中科院分区：
文献类型：
--
作者：
PATLAK, CS;BLASBERG, RG;FENSTERMACHER, JD
开发了血脑交换的理论模型，并推导了一个程序，可用于绘制多次组织摄取数据并确定在部分或全部实验期间单向转移过程是否占主导地位。如果图表表明吸收的单向性，则可以计算流入常数 (Ki)。该模型是通用的，假设线性转移动力学，并由血浆隔室、具有任意数量隔室的可逆组织区域以及 1 个或多个不可逆组织区域组成。该模型方程的解表明，应绘制采样时总组织溶质浓度与各时间血浆浓度（Cp）之比与动脉血浆浓度-时间积分与Cp之比的关系图。如果数据与该模型一致，则该图将产生一条最终变为线性的曲线，其斜率为 Ki，纵坐标截距小于或等于可逆组织区域的血管加上稳态空间。
A theoretical model of blood-brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period. If the graph indicates unidirectionality of uptake, then an influx constant (Ki) can be calculated. The model is general, assumes linear transfer kinetics and consists of a blood-plasma compartment, a reversible tissue region with an arbitrary number of compartments, and 1 or more irreversible tissue regions. The solution of the equations for this model shows that a graph of the ratio of the total tissue solute concentration at the times of sampling to the plasma concentration at the respective times (Cp) vs. the ratio of the arterial plasma concentration-time integral to Cp should be drawn. If the data are consistent with this model, then this graph will yield a curve that eventually becomes linear, with a slope of Ki and an ordinate intercept less than or equal to the vascular plus steady-state space of the reversible tissue region.