EFFECTS OF OXYGEN INHALATION ON SKIN MICROCIRCULATION IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE
EFFECTS OF OXYGEN INHALATION ON SKIN MICROCIRCULATION IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE
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DOI：
10.1161/01.cir.86.3.878
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发表时间：
1992-09-01
期刊：
影响因子：
37.8
通讯作者：
FAGRELL, B
中科院分区：
文献类型：
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作者：
BONGARD, O;BOUNAMEAUX, H;FAGRELL, B
背景资料。氧气给药目前在临床医学中被用来改善受到缺血威胁的组织的外周氧气输送。然而，关于氧气对缺血区的影响，有相互矛盾的结果报道。本研究旨在探讨40%吸氧对周围动脉闭塞症(PAOD)患者足部皮肤微循环的影响。采用激光多普勒血流仪(LDF)和动态毛细管镜(CBV)相结合的方法，对11例患者的17条足趾进行经皮氧分压(TC PO2)测定，并与8例正常人的13条足趾作对照。吸氧后上述两项指标均显著下降(Delta-LDF，-307%，p
Background. Oxygen administration is currently used in dinical medicine to improve peripheral oxygen delivery to tissues threatened by ischemia. However, conflicting results have been reported on the effects of oxygen in ischemic areas. This study was aimed at investigating the effects of 40% oxygen inhalation on the skin microcirculation in the feet of patients with peripheral arterial occlusive disease (PAOD).Methods and Results. Transcutaneous oxygen tension (tc PO2) was measured on the dorsal skin of the foot, and the nailfold microcirculation was investigated by a combination of laser Doppler flowmetry (LDF) and dynamic capillaroscopy (CBV) in the great toes of 17 legs of 11 patients, with 13 legs of eight normal subjects as a control group. Inhalation of oxygen induced a significant decrease of both the total (DELTA-LDF, -307%,p