Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid.
Synthesis of a stimulator of phosphofructokinase, most likely fructose 2,6-bisphosphate, from phosphoric acid and fructose 6-phosphoric acid.
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由磷酸和果糖 6-磷酸合成磷酸果糖激酶刺激剂，最有可能是果糖 2,6-二磷酸。
DOI：
10.1016/0006-291x(80)91347-9
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发表时间：
1980
影响因子：
3.1
通讯作者：
Hers,HG
中科院分区：
文献类型：
--
作者：
VanSchaftingen,E;Hers,HG
一种磷酸酯，具有磷酸果糖激酶的天然刺激物的所有性质，最近从大鼠肝脏中分离并暂时鉴定为果糖2，6-二磷酸[货车Schaftingen，E.，顺化湖H.G. Biochem.J.1980，出版中]通过在0 ℃或25 ℃下将85%H3PO4与0.2体积的1.8 M-果糖6-磷酸混合而形成。该结果表明，除了磷酸盐和果糖6-磷酸盐之外，没有化合物进入刺激物的结构。当反应在25°C下进行时，果糖1，6-二磷酸也以比刺激剂更慢的速率形成，但持续更长的时间。
A phosphoric ester having all the properties of the natural stimulator of phosphofructokinase recently isolated from rat liver and tentatively identified as fructose 2,6-bisphosphate [Van Schaftingen, E., Hue, L. & Hers, H.G. Biochem. J. 1980, in press] was formed by mixing 85% H3PO4with 0.2 vol of 1.8 M-fructose 6-phosphate at 0°C or 25°C. This result indicates that no compounds other than phosphate and fructose 6-phosphate enter into the structure of the stimulator. When the reaction was carried out at 25°C, fructose 1,6-bisphosphate was also formed at a slower rate than the stimulator but for a much more prolonged period.