PRETREATMENT PLASMA-LEVELS OF FIBRINOPEPTIDE-A (FPA), D-DIMER (DD), AND VON-WILLEBRAND-FACTOR (VWF) IN PATIENTS WITH OVARIAN-CARCINOMA
PRETREATMENT PLASMA-LEVELS OF FIBRINOPEPTIDE-A (FPA), D-DIMER (DD), AND VON-WILLEBRAND-FACTOR (VWF) IN PATIENTS WITH OVARIAN-CARCINOMA
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DOI：
10.1006/gyno.1994.1146
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发表时间：
1994-06-01
影响因子：
4.7
通讯作者：
FACCHINI, V
中科院分区：
文献类型：
--
作者：
GADDUCCI, A;BAICCHI, U;FACCHINI, V
本文测定了125例卵巢肿块患者术前血浆纤维蛋白肽A（FPA）、D-二聚体（DD）和血管性血友病因子（vWF）水平，并与88例健康非妊娠妇女作对照。58例卵巢癌患者的FPA、DD和vWF水平显著高于67例良性卵巢疾病患者或对照组。晚期卵巢癌（FIGO III-IV期）的FPA和DD值显著高于早期卵巢癌。在晚期患者中，FPA和DD水平与常见的临床病理预后变量无关;相反，vWF值与FIGO分期（IV vs III，P < 0.02）和初次手术后残留病变的大小（>2 cm vs小于或等于2 cm，P < 0.05）相关。总之，卵巢癌患者纤维蛋白的产生和降解增加。(C)1994年出版社出版。
The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (>2 cm versus less-than-or-equal-to 2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma. (C) 1994 Academic Press, Inc.