Endotoxemia and the host systemic response during experimental gingivitis.
Endotoxemia and the host systemic response during experimental gingivitis.
复制标题
实验性牙龈炎期间的内毒素血症和宿主全身反应。
DOI：
10.1111/j.1600-051x.2011.01710.x
复制
发表时间：
2011
影响因子：
6.7
通讯作者：
Galli,DominiqueM
中科院分区：
文献类型：
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作者：
Wahaidi,VivianY;Kowolik,MichaelJ;Eckert,GeorgeJ;Galli,DominiqueM
WAHAIDI VY，KOOILK MJ，ECKERT GJ，GALI DM：实验性牙周炎时的内毒素血症和宿主系统反应。《临床周期杂志》2011；38：412-417。材料和方法：比较50名健康的成年黑人和白人男性和女性的血清内毒素浓度和血清生物标志物[中性粒细胞氧化活性、白介素1β、白介素6、白介素8、C反应蛋白和纤维蛋白原]在基线、实验性牙周炎3周和恢复2周时的变化。结果：在诱导牙周炎3周时，56%的血清样本报告有内毒素血症。在恢复2周时，内毒素水平下降到与基线报告的水平相似。中性粒细胞氧化活性在基础牙周炎3周后显著升高(p<；0.05)。在内毒素阴性组中，这种增加与黑人有关，而在内毒素阳性组中，中性粒细胞活性的变化是由女性亚群驱动的。血清细胞因子、C反应蛋白和纤维蛋白原水平在研究期间没有变化。结论：实验性牙周炎与内毒素血症和循环中性粒细胞过度活动有关，而与全身细胞因子和急性期蛋白水平的变化无关。这可能归因于诱发性牙周炎的性质温和和持续时间短。
Wahaidi VY, Kowolik MJ, Eckert GJ, Galli DM: Endotoxemia and the host systemic response during experimental gingivitis. J Clin Periodontol 2011; 38: 412–417. doi: 10.1111/j.1600‐051X.2011.01710.x.AbstractAim:To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model.Materials and Methods:Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)‐1β, IL‐6, IL‐8, C‐reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance.Results:Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitisversusbaseline (p<0.05). In the endotoxin‐negative group this increase was associated with the black subjects whereas in the endotoxin‐positive group change in neutrophil activity was driven by the female subpopulation. Serum cytokines, CRP, and fibrinogen levels did not change during the study.Conclusions:Experimental gingivitis was associated with endotoxemia and hyperactivity of circulating neutrophils, but not with changes in systemic levels of cytokines and acute‐phase proteins. This may be attributed to the mild nature and the short duration of the induced gingivitis.