Cell cycle regulation by protein degradation.
Cell cycle regulation by protein degradation.
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DOI：
10.1007/978-1-4939-0888-2_4
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发表时间：
2014
影响因子：
--
通讯作者：
D. Koepp
中科院分区：
文献类型：
--
作者：
D. Koepp
细胞分裂由高度调节的程序控制，以准确复制和分离染色体。细胞周期调控程序的一个重要特征是关键细胞周期蛋白在特定细胞周期阶段存在并具有活性，但随后被去除或抑制以维持适当的时间。泛素-蛋白酶体系统已经成为一种重要的机制，在细胞分裂的关键时刻降解细胞周期蛋白。靶向关键细胞周期蛋白的两种关键E3泛素连接酶复合物是Skp 1-Cul 1-F-box蛋白复合物和后期促进复合物/细胞周期小体。本章重点介绍了这些E3泛素连接酶的作用，以及中央细胞周期调控蛋白的泛素依赖性降解如何推进细胞周期。
Cell division is controlled by a highly regulated program to accurately duplicate and segregate chromosomes. An important feature of the cell cycle regulatory program is that key cell cycle proteins are present and active during specific cell cycle stages but are later removed or inhibited to maintain appropriate timing. The ubiquitin–proteasome system has emerged as an important mechanism to target cell cycle proteins for degradation at critical junctures during cell division. Two key E3 ubiquitin ligase complexes that target key cell cycle proteins are the Skp1–Cul1–F-box protein complex and the anaphase-promoting complex/cyclosome. This chapter focuses on the role of these E3 ubiquitin ligases and how ubiquitin-dependent degradation of central cell cycle regulatory proteins advances the cell cycle.