Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume.
Continuous measurement of object location memory is sensitive to effects of age and mild cognitive impairment and related to medial temporal lobe volume.
复制标题
DOI：
10.1016/j.dadm.2017.10.007
复制
发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Sathian, Krishnankutty
中科院分区：
文献类型：
--
作者：
Hampstead, Benjamin M;Towler, Stephen;Sathian, Krishnankutty
我们介绍了一种新颖的生态相关联想记忆测试的发现，即物体定位触屏测试（OLTT），该测试被认为对轻度认知障碍（MCI）相关的早期内侧颞叶损害敏感。方法：114名参与者，包括健康的年轻人和老年人对照以及MCI患者，完成了OLTT和标准神经心理测试。OLTT要求参与者在自由回忆和提示回忆条件下回忆物体的位置，并使用距离测量（即连续错误评分）和标准识别格式来评估准确性。从77名参与者的子集中评估了性能和体积数据之间的相关性。结果：在所有测试条件下，显著的年龄效应与MCI效应相比都相形见绌。OLTT提示回忆与疾病相关的内侧颞叶区域的体积密切相关，通常比传统记忆测试更明显。讨论：OLTT可能对阿尔茨海默病影响区域的早期结构损害敏感。
INTRODUCTION: We present findings of a novel and ecologically relevant associative memory test, the Object Location Touchscreen Test (OLTT), which was posited as sensitive to early medial temporal lobe compromise associated with mild cognitive impairment (MCI).METHODS: A total of 114 participants, including healthy young and older controls and patients with MCI, completed the OLTT and standard neuropsychological testing. The OLTT required participants to recall the location of objects under free and cued recall conditions, with accuracy evaluated using distance measures (i.e., a continuous error score), and a standard recognition format. Correlations between performance and volumetric data were evaluated from a subset of 77 participants.RESULTS: Significant age effects were dwarfed by MCI effects across all test conditions. OLTT Cued Recall was strongly and specifically related to the volume of disease-relevant medial temporal lobe regions, generally more than traditional memory tests.DISCUSSION: The OLTT may be sensitive to early structural compromise in regions affected by Alzheimer's disease.