A rodent model of focally evoked self-sustaining status epilepticus.
A rodent model of focally evoked self-sustaining status epilepticus.
复制标题
局灶性诱发自我维持癫痫持续状态的啮齿动物模型。
DOI：
10.1016/0014-2999(92)90785-3
复制
发表时间：
1992
影响因子：
5
通讯作者：
Gale,K
中科院分区：
文献类型：
--
作者：
Peterson,CJ;Vinayak,S;Pazos,A;Gale,K
我们描述了一种新的癫痫持续状态模型，该模型通过将荷包牡丹碱（bicuculline mccithiodidc）局部应用于氯化锂预处理的大鼠的梨状皮质深部而产生。3/8只大鼠在局灶性荷包牡丹碱诱导癫痫发作前24 h给予1剂锂（3 mmol/kg）预处理，8/12只大鼠在诱导癫痫发作前24 h和48 h给予2剂锂预处理，均出现持续不间断的惊厥发作（癫痫持续状态），持续时间为10 min ~> 2 h。这种癫痫持续状态在行为学和脑电图上都有表现，可通过地西泮（5 mg/kg，i. p.）在持续癫痫持续状态发作后2小时给予。匹罗卡品（25 mg/kg）也易诱发响应于荷包牡丹碱局部应用的癫痫持续状态，但地西泮（5或10 mg/kg i. p.）在匹鲁卡品存在的情况下，对抑制癫痫持续状态无效。
We describe a novel model of status epilepticus produced by the focal application of bicuculline mcthiodidc into the deep prcpiriform cortex of rats prctreatcd with lithium chloride. Three out of eight rats pretrcated with one dose of lithium (3 mmol/kg) 24 h prior to induction of seizures by focal bicucullinc, and eight out of 12 rats pretrealed with two doses of lithium (at 24 and 48 h) prior to seizure induction, exhibitedcontinualuninterrupted convulsive seizure activity (status epilepticus) lasting between 10 min and > 2 h. This status epilepticus which was manifest both behaviorally and elcetroencephalographically, was scnsilive to reversal by diazepam (5 mg/kg i.p.) given as long as 2 h after the onset of sustained status epilepticus. Pilocarpinc (25 mg/kg) prctrcatment also predisposed to status epilepticus in response to the focal application of bicuculline, but diazepam (5 or 10 mg/kg i.p.) was ineffective in suppressing the status epilepticus in the presence of pilocarpine.